CD1 Antibody (76-7-4): sc-52454

CD1 Antibody (76-7-4) is a mouse monoclonal IgG2a antibody that detects CD1 protein of porcine origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD1 antibody (76-7-4) is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. CD1 protein is a crucial component of the immune system, functioning as a lipid antigen-presenting molecule that interacts with T lymphocytes. CD1 protein is primarily located on the surface of immune cells such as cortical thymocytes, Langerhans cells, and certain dendritic cells, where CD1 plays a vital role in the recognition of lipid-based antigens. The structural similarity of CD1 to MHC class I molecules allows CD1 to present these lipid antigens effectively, which is essential for the activation of CD1-restricted T cells. The CD1 multigene family includes five isoforms in humans—CD1A, CD1B, CD1C, CD1D, and CD1E—each with specific roles in immune responses. CD1A serves as a marker for Langerhans cell histiocytosis and is found on interdigitating cells, highlighting CD1A′s importance in both immune surveillance and pathology. The trafficking of CD1 proteins is tightly regulated by adaptor-protein complexes and chaperones, ensuring proper immune function and response. The human CD1 genes are clustered on chromosome 1q 22-23, reflecting their evolutionary relationship and functional interdependence.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD1 Antibody (76-7-4) References:

1. New insights into pathways for CD1-mediated antigen presentation.  |  Sugita, M., et al. 2004. Curr Opin Immunol. 16: 90-5. PMID: 14734115
2. CD1: antigen presentation and T cell function.  |  Brigl, M. and Brenner, MB. 2004. Annu Rev Immunol. 22: 817-90. PMID: 15032598
3. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.  |  Martin, LH., et al. 1987. Proc Natl Acad Sci U S A. 84: 9189-93. PMID: 2447586
4. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.  |  Aruffo, A. and Seed, B. 1989. J Immunol. 143: 1723-30. PMID: 2701945
5. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.  |  Longley, J., et al. 1989. J Invest Dermatol. 92: 628-31. PMID: 2784820
6. The CD1 family: a third lineage of antigen-presenting molecules.  |  Porcelli, SA. 1995. Adv Immunol. 59: 1-98. PMID: 7484459
7. Surface antigens of human thymocyte populations defined by CD3, CD4 and CD8 expression: CD1a is expressed by mature thymocytes but not peripheral T cells.  |  Sotzik, F., et al. 1993. Immunol Lett. 36: 101-6. PMID: 7688345
8. Class I-like CD1A-C do not protect target cells from NK-mediated cytolysis.  |  Storkus, WJ., et al. 1996. Cell Immunol. 167: 154-6. PMID: 8548840
9. Antigen presentation by CD1 and MHC-encoded class I-like molecules.  |  Melián, A., et al. 1996. Curr Opin Immunol. 8: 82-8. PMID: 8729450
10. Analysis of the requirement for beta 2-microglobulin for expression and formation of human CD1 antigens.  |  Bauer, A., et al. 1997. Eur J Immunol. 27: 1366-73. PMID: 9209486