Molecular structure of CD 437, CAS Number: 125316-60-1
CD 437 (CAS 125316-60-1)
Alternate Names:
AHPN; 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Application:
CD 437 is A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
CAS Number:
125316-60-1
Molecular Weight:
398.49
Molecular Formula:
C27H26O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.
CD 437 (CAS 125316-60-1) References
- Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3. | Liang, JY., et al. 1999. Prostate. 38: 228-36. PMID: 10068347
- Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids. | Diaz, BV., et al. 2000. J Biol Chem. 275: 642-50. PMID: 10617662
- The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus. | Marchetti, P., et al. 1999. Cancer Res. 59: 6257-66. PMID: 10626821
- Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation. | Costa, SL., et al. 2001. Eur J Cancer. 37: 520-30. PMID: 11267863
- Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor. | Paillaud, E., et al. 2002. J Neurosci Res. 67: 670-9. PMID: 11891779
- Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design. | Los, M., et al. 2003. Drug Discov Today. 8: 67-77. PMID: 12565009
- The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. | Zhao, X. and Spanjaard, RA. 2003. J Biomed Sci. 10: 44-9. PMID: 12566985
- Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines. | Holmes, WF., et al. 2004. J Cell Physiol. 199: 317-29. PMID: 15095280
- GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells. | Jiang, T., et al. 2007. J Cell Physiol. 212: 771-9. PMID: 17474084
- CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling. | Watanabe, Y., et al. 2008. Biochem Biophys Res Commun. 366: 840-7. PMID: 18082618
- Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | Mukhopadhyay, B., et al. 2010. J Biol Chem. 285: 19002-11. PMID: 20410309
- Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review. | Marchwicka, A., et al. 2016. Expert Opin Ther Pat. 26: 957-71. PMID: 27336223
- Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition. | Jaiquel Baron, S., et al. 2021. Theranostics. 11: 5077-5091. PMID: 33859735
- Mechanism underlying retinoic acid-dependent metamorphosis in the starfish. | Yamakawa, S., et al. 2022. Dev Biol. 492: 119-125. PMID: 36240875
- A selective retinoid with high activity against an androgen-resistant prostate cancer cell type. | Lu, XP., et al. 1999. Int J Cancer. 80: 272-8. PMID: 9935210
Inhibitor of:
RAI3, and Sec61β.Activator of:
IRX2, RAR beta, RAR gamma, and RORβ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD 437, 5 mg | sc-202527 | 5 mg | $121.00 |