Date published: 2025-11-22

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CD 3254 (CAS 196961-43-0)

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Alternate Names:
3-[4-Hydroxy-3-(5,6,7,8-tetrahtdro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
Application:
CD 3254 is a selective RXRα agonist
CAS Number:
196961-43-0
Purity:
≥97%
Molecular Weight:
364.48
Molecular Formula:
C24H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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CD 3254, a synthetic retinoid, exhibits selective modulation of retinoic acid receptors (RARs), particularly favoring the RARβ and RARγ subtypes over RARα. Unlike other retinoids that indiscriminately activate all RAR subtypes, CD 3254′s selectivity allows for more targeted research into the specific roles and mechanisms these receptors play in cellular differentiation, proliferation, and apoptosis. This specificity holds significant promise for elucidating the pathways through which retinoids influence gene expression and cellular processes. In research applications, CD 3254 is utilized to dissect the intricate balance of retinoid activities that underlie various biological phenomena, including embryonic development and the maintenance of epithelial tissues. Its mechanism of action involves altering the transcription of genes that are critical for cell cycle regulation and differentiation, thereby providing useful for investigating the molecular underpinnings of retinoid function and their impact on cellular behavior.


CD 3254 (CAS 196961-43-0) References

  1. Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands.  |  Balaguer, P., et al. 2001. Luminescence. 16: 153-8. PMID: 11312541
  2. Co-regulator recruitment and the mechanism of retinoic acid receptor synergy.  |  Germain, P., et al. 2002. Nature. 415: 187-92. PMID: 11805839
  3. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.  |  Pogenberg, V., et al. 2005. J Biol Chem. 280: 1625-33. PMID: 15528208
  4. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.  |  Nahoum, V., et al. 2007. Proc Natl Acad Sci U S A. 104: 17323-8. PMID: 17947383
  5. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.  |  le Maire, A., et al. 2009. EMBO Rep. 10: 367-73. PMID: 19270714
  6. Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.  |  Pérez Santín, E., et al. 2009. J Med Chem. 52: 3150-8. PMID: 19408900
  7. Divergent teratogenicity of agonists of retinoid X receptors in embryos of zebrafish (Danio rerio).  |  Shi, H., et al. 2012. Ecotoxicology. 21: 1465-75. PMID: 22526925
  8. Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254).  |  Jurutka, PW., et al. 2013. J Med Chem. 56: 8432-54. PMID: 24180745
  9. Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes.  |  Shiizaki, K., et al. 2014. J Pharmacol Toxicol Methods. 69: 245-52. PMID: 24530888
  10. Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds.  |  Staal, YCM., et al. 2018. Arch Toxicol. 92: 3549-3564. PMID: 30288550
  11. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis.  |  Ishihara, Y., et al. 2019. J Steroid Biochem Mol Biol. 193: 105421. PMID: 31265900
  12. Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures.  |  Heusinkveld, HJ., et al. 2020. Reprod Toxicol. 96: 114-127. PMID: 32553615
  13. An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene.  |  Jurutka, PW., et al. 2022. Int J Mol Sci. 23: PMID: 36555852

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CD 3254, 10 mg

sc-358786
10 mg
$280.00
US: Only available in the US

CD 3254, 50 mg

sc-358786A
50 mg
$1155.00
US: Only available in the US