Molecular structure of CCT241533, CAS Number: 1262849-73-9
CCT241533 (CAS 1262849-73-9)
Alternate Names:
CCT 241533;CCT-241533
CAS Number:
1262849-73-9
Molecular Weight:
442.48
Molecular Formula:
C23H27FN4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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CCT241533 (CAS 1262849-73-9) References
- Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. | Caldwell, JJ., et al. 2011. J Med Chem. 54: 580-90. PMID: 21186793
- CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. | Anderson, VE., et al. 2011. Cancer Res. 71: 463-72. PMID: 21239475
- Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. | Raleigh, DR. and Haas-Kogan, DA. 2013. Future Oncol. 9: 219-33. PMID: 23414472
- Role of CHK2 inhibitors in the cellular responses to ionizing radiation. | Zahmatkesh, MH., et al. 2014. Mini Rev Med Chem. 14: 812-8. PMID: 25307309
- Trimethylation of histone H3K76 by Dot1B enhances cell cycle progression after mitosis in Trypanosoma cruzi. | Nunes, VS., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118694. PMID: 32151656
- EZH2-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress. | León, TE., et al. 2020. Cancer Discov. 10: 998-1017. PMID: 32349972
- DNA damage checkpoint kinases in cancer. | Smith, HL., et al. 2020. Expert Rev Mol Med. 22: e2. PMID: 32508294
- Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury. | Taylor, MJ., et al. 2022. Sci Adv. 8: eabq2611. PMID: 36103534
- Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer. | Qin, S., et al. 2023. Int J Mol Sci. 24: PMID: 37373360
- Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays. | Van Vranken, JG., et al. 2024. bioRxiv.. PMID: 38328090
Inhibitor of:
ERK 1, and TSSK 6.Activator of:
EID-3, ERK 1, and Smurf2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCT241533, 10 mg | sc-507308 | 10 mg | $440.00 |