Molecular structure of CCT007093, CAS Number: 176957-55-4
CCT007093 (CAS 176957-55-4)
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Alternate Names:
(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone
Application:
CCT007093 is an inhibitor of Wip1 (PPM1D)
CAS Number:
176957-55-4
Molecular Weight:
272.39
Molecular Formula:
C15H12OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CCT007093 is a small molecule inhibitor that targets the protein kinase PDK1. CCT007093 inhibits the phosphorylation of PDK1 substrates, thereby affecting various cellular processes such as cell growth, survival, and metabolism. CCT007093 blocks the PI3K/Akt signaling pathway, which is for cancer cell proliferation and survival. By inhibiting PDK1, CCT007093 has the potential to disrupt the growth and survival of cancer cells. CCT007093 exhibits anti-inflammatory properties by modulating the activity of immune cells. CCT007093 shows promise for studying PDK1 signaling and its role in various cellular processes.
CCT007093 (CAS 176957-55-4) References
- Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. | Bulavin, DV., et al. 2002. Nat Genet. 31: 210-5. PMID: 12021785
- A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. | Rayter, S., et al. 2008. Oncogene. 27: 1036-44. PMID: 17700519
- PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53. | Pärssinen, J., et al. 2008. Cancer Genet Cytogenet. 182: 33-9. PMID: 18328948
- PPM1D is a potential therapeutic target in ovarian clear cell carcinomas. | Tan, DS., et al. 2009. Clin Cancer Res. 15: 2269-80. PMID: 19293255
- RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. | Bauer, JA., et al. 2010. Breast Cancer Res. 12: R41. PMID: 20576088
- HDM2 promotes WIP1-mediated medulloblastoma growth. | Buss, MC., et al. 2012. Neuro Oncol. 14: 440-58. PMID: 22379189
- [Role of serine/threonine and tyrosine protein phosphatases in command Helix lucorum neurons at the cellular correlate of habituation]. | Pivovarov, AS., et al. 2013. Zh Vyssh Nerv Deiat Im I P Pavlova. 63: 256-68. PMID: 23866612
- Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. | Lee, JS., et al. 2014. J Dermatol Sci. 73: 125-34. PMID: 24126074
- Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. | Zhang, L., et al. 2015. Hepatology. 61: 2030-41. PMID: 25704606
- Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury. | Mou, Q., et al. 2021. J Inflamm Res. 14: 6857-6869. PMID: 34934336
- Prognostic risk assessment model and drug sensitivity analysis of colon adenocarcinoma (COAD) based on immune-related lncRNA pairs. | Hao, Z., et al. 2022. BMC Bioinformatics. 23: 435. PMID: 36258178
- Prognostic value of nicotinamide adenine dinucleotide (NAD+) metabolic genes in patients with stomach adenocarcinoma based on bioinformatics analysis. | Cai, L., et al. 2022. J Gastrointest Oncol. 13: 2845-2862. PMID: 36636067
- Identification and validation of a novel CD8+ T cell-associated prognostic model based on ferroptosis in acute myeloid leukemia. | Jiang, G., et al. 2023. Front Immunol. 14: 1149513. PMID: 37138885
Inhibitor of:
Wip1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCT007093, 5 mg | sc-214673 | 5 mg | $94.00 | |||
CCT007093, 25 mg | sc-214673A | 25 mg | $375.00 | |||
CCT007093, 50 mg | sc-214673B | 50 mg | $459.00 |