Molecular structure of CCR4 Antagonist, CAS Number: 864289-85-0
CCR4 Antagonist (CAS 864289-85-0)
See product citations (7)
Alternate Names:
2-(1,4′-Bipiperidin)-1′-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine; C-021
Application:
CCR4 Antagonist is a diaminoquinazoline compound and potent antagonist of CCR4
CAS Number:
864289-85-0
Purity:
≥97%
Molecular Weight:
467.66
Molecular Formula:
C27H41N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CCR4 Antagonist is a cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CKR-4 (CCR4). CCR4 Antagonist is shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures. The CCR4 receptor primarily binds to certain chemokines, particularly CCL17 (TARC) and CCL22 (MDC). These chemokines are involved in the directed migration (chemotaxis) of specific immune cells, notably T-helper type 2 (Th2) lymphocytes. Th2 cells are implicated in allergic responses and certain other immune responses. CCR4 can be overexpressed on certain cancer cells, particularly some types of T-cell leukemia and lymphoma. Blocking CCR4 might impair the migration and survival of these cancer cells.
CCR4 Antagonist (CAS 864289-85-0) References
- Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. | Yokoyama, K., et al. 2008. Bioorg Med Chem. 16: 7021-32. PMID: 18539035
- Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment. | McLane, JS. and Ligon, LA. 2015. Biophys J. 109: 249-64. PMID: 26200861
- Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1. | Lai, SW., et al. 2019. Nutrients. 11: PMID: 31207928
- Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells. | Valente, M., et al. 2019. Proc Natl Acad Sci U S A. 116: 25816-25827. PMID: 31796596
- CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma. | Gao, Y., et al. 2020. Pharmacol Res. 157: 104800. PMID: 32278046
- CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain. | Bogacka, J., et al. 2020. Eur J Pharmacol. 880: 173166. PMID: 32407723
- Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia - Evidence from a Mouse Model of Diabetic Neuropathy. | Bogacka, J., et al. 2020. Neuroscience. 441: 77-92. PMID: 32592824
- CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain. | Bogacka, J., et al. 2020. Front Immunol. 11: 1241. PMID: 32760393
- Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice. | Deng, S., et al. 2020. Neurotherapeutics. 17: 1940-1953. PMID: 32783091
- Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice. | Deng, S., et al. 2021. J Neuroinflammation. 18: 62. PMID: 33648537
- Chemokine receptor antagonists with α1-adrenergic receptor blocker activity. | DeSantis, AJ., et al. 2021. J Basic Clin Physiol Pharmacol. 33: 519-523. PMID: 34144642
- Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons. | Silva, JR., et al. 2022. Proc Natl Acad Sci U S A. 119: PMID: 35046040
- CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling. | Wang, QR., et al. 2023. Biochem Pharmacol. 210: 115475. PMID: 36870575
Inhibitor of:
CKR-4, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCR4 Antagonist, 1 mg | sc-221406A | 1 mg | $82.00 | |||
CCR4 Antagonist, 5 mg | sc-221406 | 5 mg | $112.00 | |||
CCR4 Antagonist, 10 mg | sc-221406B | 10 mg | $139.00 |