Molecular structure of CCMI, CAS Number: 917837-54-8
CCMI (CAS 917837-54-8)
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Application:
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors
CAS Number:
917837-54-8
Molecular Weight:
388.25
Molecular Formula:
C19H15Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). This compound has been shown to induce a positive modulation of acetylcholine (ACh)-induced EC5 currents.
CCMI (CAS 917837-54-8) References
- Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. | Ng, HJ., et al. 2007. Proc Natl Acad Sci U S A. 104: 8059-64. PMID: 17470817
- Cytogenetic study of a papillary thyroid carcinoma with a rearranged chromosome 10. | Herrmann, ME., et al. 1991. Cancer Genet Cytogenet. 57: 209-17. PMID: 1756500
- Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. | Hu, M., et al. 2009. Br J Pharmacol. 158: 1857-64. PMID: 20050184
- Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats. | Nikiforuk, A., et al. 2016. Neuropharmacology. 101: 389-400. PMID: 26232639
- The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors. | Nikiforuk, A., et al. 2016. Behav Brain Res. 313: 214-218. PMID: 27435422
- Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats. | Potasiewicz, A., et al. 2017. J Psychopharmacol. 31: 260-271. PMID: 28168926
- The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials. | Yang, T., et al. 2017. Acta Pharm Sin B. 7: 611-622. PMID: 29159020
- Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning. | Milienne-Petiot, M., et al. 2018. Eur Neuropsychopharmacol. 28: 1217-1231. PMID: 30213668
- Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats. | Potasiewicz, A., et al. 2020. Behav Brain Res. 385: 112547. PMID: 32087183
- Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats. | Unal, G., et al. 2020. Pharmacol Biochem Behav. 193: 172916. PMID: 32220620
- α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats. | Unal, G., et al. 2021. Behav Brain Res. 397: 112946. PMID: 33011186
- Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats. | Potasiewicz, A., et al. 2021. Behav Brain Res. 409: 113338. PMID: 33940049
- The Effects of Positive Allosteric Modulators of α7-nAChR on Social Play Behavior in Adolescent Rats Prenatally Exposed to Valproic Acid. | Gzielo, K. and Nikiforuk, A. 2022. Pharmaceuticals (Basel). 15: PMID: 36422547
Activator of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCMI, 10 mg | sc-361135 | 10 mg | $140.00 | |||
CCMI, 50 mg | sc-361135A | 50 mg | $588.00 |