CCL28 Antibody (G-2): sc-376654
- CCL28 Antibody (G-2) is a mouse monoclonal IgG1 κ CCL28 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 103-130 at the C-terminus of CCL28 of mouse origin
- CCL28 Antibody (G-2) is recommended for detection of CCL28 of mouse origin by WB, IP, IF and ELISA
- Anti-CCL28 Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CCL28 Antibody (G-2). This work is in progress.
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CCL28 Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCL28 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCL28 (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCL28 plays a crucial role in the immune response by mediating chemotactic activity for resting CD4 and CD8 T cells, as well as eosinophils, which are essential for orchestrating immune responses and inflammation. This secreted protein binds to chemokine receptors CCR3 and CCR10, previously known as orphan G protein-coupled receptor GPR2, leading to calcium mobilization in a dose-dependent manner, which is vital for activation and migration of immune cells to sites of inflammation. CCL28 is predominantly expressed by epithelial cells in various tissues, including colon, salivary gland, mammary gland, trachea, and rectum, highlighting CCL28′s importance in both normal physiological processes and pathological conditions. Additionally, CCL28 belongs to the subfamily of small cytokine CC genes, characterized by the presence of two adjacent cysteines, and several alternative splice variants may exist, further diversifying CCL28′s functional roles in the immune system.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCL28 Antibody (G-2) References:
- Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). | Wang, W., et al. 2000. J Biol Chem. 275: 22313-23. PMID: 10781587
- CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. | Hieshima, K., et al. 2003. J Immunol. 170: 1452-61. PMID: 12538707
- A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. | Lazarus, NH., et al. 2003. J Immunol. 170: 3799-805. PMID: 12646646
- Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells. | Hanamoto, H., et al. 2004. Am J Pathol. 164: 997-1006. PMID: 14982853
- CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. | Wilson, E. and Butcher, EC. 2004. J Exp Med. 200: 805-9. PMID: 15381732
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCL28 Antibody (G-2) | sc-376654 | 200 µg/ml | $316.00 | |||
CCL28 Antibody (G-2) AC | sc-376654 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCL28 Antibody (G-2) HRP | sc-376654 HRP | 200 µg/ml | $316.00 | |||
CCL28 Antibody (G-2) FITC | sc-376654 FITC | 200 µg/ml | $330.00 | |||
CCL28 Antibody (G-2) PE | sc-376654 PE | 200 µg/ml | $343.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 488 | sc-376654 AF488 | 200 µg/ml | $357.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 546 | sc-376654 AF546 | 200 µg/ml | $357.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 594 | sc-376654 AF594 | 200 µg/ml | $357.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 647 | sc-376654 AF647 | 200 µg/ml | $357.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 680 | sc-376654 AF680 | 200 µg/ml | $357.00 | |||
CCL28 Antibody (G-2) Alexa Fluor® 790 | sc-376654 AF790 | 200 µg/ml | $357.00 | |||
CCL28 (G-2) Neutralizing Peptide | sc-376654 P | 100 µg/0.5 ml | $68.00 |