Molecular structure of CCG-1423, CAS Number: 285986-88-1
CCG-1423 (CAS 285986-88-1)
See product citations (8)
Alternate Names:
N-[2-[4(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide
Application:
CCG-1423 is an inhibitor of Rho pathway-mediated signaling and activation of serum response factor transcription
CAS Number:
285986-88-1
Molecular Weight:
454.75
Molecular Formula:
C18H13ClF6N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CCG-1423 is a specific inhibitor of Rho pathway-mediated signalling and activation of serum response factor (SRF) transcription. The Rho family of small GTPases play a vital role in transduction of cell signalling events associated with several human cancers. It inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active Galpha13 with an IC50 value of 1 muM. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.
CCG-1423 (CAS 285986-88-1) References
- CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. | Evelyn, CR., et al. 2007. Mol Cancer Ther. 6: 2249-60. PMID: 17699722
- Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. | Evelyn, CR., et al. 2010. Bioorg Med Chem Lett. 20: 665-72. PMID: 19963382
- Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway. | Bell, JL., et al. 2013. Beilstein J Org Chem. 9: 966-73. PMID: 23766813
- RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. | Hayashi, K., et al. 2014. PLoS One. 9: e89016. PMID: 24558465
- Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. | Watanabe, B., et al. 2015. PLoS One. 10: e0136242. PMID: 26295164
- Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis. | Gau, D., et al. 2017. Angiogenesis. 20: 663-672. PMID: 28638990
- Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons. | Kikuchi, K., et al. 2017. Biochem Biophys Res Commun. 492: 474-479. PMID: 28830810
- Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury. | Yu, L., et al. 2018. Circulation. 138: 2820-2836. PMID: 30018168
- Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds. | Lisabeth, EM., et al. 2019. ACS Pharmacol Transl Sci. 2: 92-100. PMID: 32039344
- Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells. | Ding, Y., et al. 2021. Environ Pollut. 280: 116974. PMID: 33784569
- Inhibition of RhoA/MRTF-A signaling alleviates nucleus pulposus fibrosis induced by mechanical stress overload. | Song, M., et al. 2022. Connect Tissue Res. 63: 53-68. PMID: 34420462
- Enriching the Arsenal of Pharmacological Tools against MICAL2. | Barravecchia, I., et al. 2021. Molecules. 26: PMID: 34946600
- Rho/SRF Inhibitor Modulates Mitochondrial Functions. | Patyal, P., et al. 2022. Int J Mol Sci. 23: PMID: 36232837
Inhibitor of:
α-parvin, 4932411E22Rik, A430078G23Rik, A730069N07Rik, AGP-3, ARHGAP21, ARHGEF10L, ARHGEF37, ARHGEF38, ARHGEF5L, ARID2, AS250, BAIAP2L2, C8orf80, C9orf100, CCDC142, CLYBL, COL11A1, CRIP1, E130112L23Rik, EG432555, EG432879, FBLIM1, Filamin 3, Fndc3c1, Gα 13, Gbp9, GLIPR1, Gm14137, GPR142, hemicentin-1, IQGAP1, JMY, KIAA1199, Laminin β-2, LARG, Lbc, Liprin β1, LMO7, LPP, Malcavernin, MIZIP, MRTF-A, MRTF-B, Myocardin, NET1, oligophrenin-1, PABP, PABPC2, PABPC3, PABPC6, Pinch-1, Pinch-3, PLEK2, PLEKHG5, Ral GDS, RasGRP1, RGNEF, Rho, Rho A, Rho C, Rho F, Rho G, Rho GAP p190B, Rho H, Rho J, Rho T1, Rho V, Rhotekin, RILPL1, RIP/Rab, Rnd1, RSU1, SAV1, Skn-1i, SRF, Syne-1, TFIIB, Vimentin, and WIRE.Activator of:
β-parvin, AAK1, ACTG2, ARAP1, ARHGAP10, ARHGAP11B, ARHGAP30, ARHGAP36, ARHGAP8, ARHGEF17, BC057079, C20orf95, eIF4B, FHOD1, FRMD6, PDZ-RhoGEF, R7BP, Rho B, Rho GAP p190-B, Rho GDIγ, RhoGEF p115_Lsc, RYK, SEMA3G, and SEMA4F.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCG-1423, 1 mg | sc-205241 | 1 mg | $30.00 | |||
CCG-1423, 5 mg | sc-205241A | 5 mg | $90.00 |