CBX6 Antibody (H-1): sc-393040
- CBX6 Antibody (H-1) is a mouse monoclonal IgG2a κ CBX6 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 342-369 near the C-terminus of CBX6 of human origin
- CBX6 Antibody (H-1) is recommended for detection of CBX6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- TransCruz reagent for ChIP application (sc-393040 X, 200 µg/0.1 ml)
- Anti-CBX6 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CBX6 Antibody (H-1) for WB applications. These reagents are now offered in bundles with CBX6 Antibody (H-1) (see ordering information below).
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CBX6 Antibody (H-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects CBX6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CBX6 (H-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CBX6, also known as chromobox protein homolog 6, is a crucial component of the polycomb group (PcG) complex, which plays a significant role in regulating gene expression patterns associated with development and cell proliferation. This 412 amino acid protein is characterized by a chromobox (CHR) domain, a 37 amino acid motif essential for targeting chromodomain proteins to specific nuclear regions, thereby influencing chromatin structure and function. CBX6′s ability to modify chromatin and maintain a transcriptionally repressive state is vital for proper cellular function and development, ensuring genes are expressed at the right time and context. Using anti-CBX6 antibody (H-1) in research can provide insights into regulatory mechanisms of gene expression and chromatin dynamics in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CBX6 Antibody (H-1) References:
- Stabilization of chromatin structure by PRC1, a Polycomb complex. | Shao, Z., et al. 1999. Cell. 98: 37-46. PMID: 10412979
- Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. | Müller, J., et al. 2002. Cell. 111: 197-208. PMID: 12408864
- The mouse has a Polycomb-like chromobox gene. | Pearce, JJ., et al. 1992. Development. 114: 921-9. PMID: 1352241
- Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. | Bernstein, E., et al. 2006. Mol Cell Biol. 26: 2560-9. PMID: 16537902
- Role of the chromobox protein CBX7 in lymphomagenesis. | Scott, CL., et al. 2007. Proc Natl Acad Sci U S A. 104: 5389-94. PMID: 17374722
- Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a. | Li, B., et al. 2007. Biochem J. 405: 369-78. PMID: 17439403
- Dynamic changes in localization of Chromobox (Cbx) family members during the maternal to embryonic transition. | Ruddock-D'Cruz, NT., et al. 2008. Mol Reprod Dev. 75: 477-88. PMID: 17486619
- Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. | Vincenz, C. and Kerppola, TK. 2008. Proc Natl Acad Sci U S A. 105: 16572-7. PMID: 18927235
- Chicken chromobox proteins: cDNA cloning of CHCB1, -2, -3 and their relation to W-heterochromatin. | Yamaguchi, K., et al. 1998. Exp Cell Res. 242: 303-14. PMID: 9665828
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBX6 Antibody (H-1) | sc-393040 | 200 µg/ml | $322.00 | |||
CBX6 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-523782 | 200 µg Ab, 40 µg BP | $361.00 | |||
CBX6 Antibody (H-1): m-IgG2a BP-HRP Bundle | sc-546168 | 200 µg Ab; 10 µg BP | $361.00 | |||
CBX6 Antibody (H-1) X | sc-393040 X | 200 µg/0.1 ml | $322.00 | |||
CBX6 Antibody (H-1) AC | sc-393040 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CBX6 Antibody (H-1) HRP | sc-393040 HRP | 200 µg/ml | $322.00 | |||
CBX6 Antibody (H-1) FITC | sc-393040 FITC | 200 µg/ml | $336.00 | |||
CBX6 Antibody (H-1) PE | sc-393040 PE | 200 µg/ml | $349.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 488 | sc-393040 AF488 | 200 µg/ml | $364.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 546 | sc-393040 AF546 | 200 µg/ml | $364.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 594 | sc-393040 AF594 | 200 µg/ml | $364.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 647 | sc-393040 AF647 | 200 µg/ml | $364.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 680 | sc-393040 AF680 | 200 µg/ml | $364.00 | |||
CBX6 Antibody (H-1) Alexa Fluor® 790 | sc-393040 AF790 | 200 µg/ml | $364.00 | |||
CBX6 (H-1) Neutralizing Peptide | sc-393040 P | 100 µg/0.5 ml | $69.00 |