Molecular structure of CBiPES hydrochloride, CAS Number: 856702-40-4
CBiPES hydrochloride (CAS 856702-40-4)
Application:
CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2
CAS Number:
856702-40-4
Molecular Weight:
413.92
Molecular Formula:
C21H19N3O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CBiPES hydrochloride is a selective positive allosteric modulator of the mGluR-2. In vivo, CBiPES hydrochloride, attenuates ketamine-evoked histamine release.
CBiPES hydrochloride (CAS 856702-40-4) References
- Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). | Johnson, MP., et al. 2005. Psychopharmacology (Berl). 179: 271-83. PMID: 15717213
- Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge. | Fell, MJ., et al. 2010. Neuropharmacology. 58: 632-9. PMID: 19951716
- Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders. | Gregory, KJ., et al. 2013. Prog Mol Biol Transl Sci. 115: 61-121. PMID: 23415092
- Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators. | Fulton, MG., et al. 2019. Lett Drug Des Discov. 16: 1387-1394. PMID: 32201485
Activator of:
mGluR-2.Substrate of:
mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBiPES hydrochloride, 10 mg | sc-358830 | 10 mg | $145.00 | |||
CBiPES hydrochloride, 50 mg | sc-358830A | 50 mg | $645.00 |