Molecular structure of CBHA, CAS Number: 174664-65-4
CBHA (CAS 174664-65-4)
See product citations (2)
Alternate Names:
Histone Deacetylase Inhibitor II; m-Carboxycinnamic Acid bis-Hydroxamide
Application:
CBHA is a potent HDAC inhibitor
CAS Number:
174664-65-4
Purity:
≥98%
Molecular Weight:
222.2
Molecular Formula:
C10H10N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and 0.07 muM in vitro for HDAC1 and HDAC3, respectively. Also induces apoptosis in nine different neuroblastoma cell lines in culture. CBHA also completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg. Addition of retinoic acid increases efficacy of CBHA for suppressing tumor growth in mice.
CBHA (CAS 174664-65-4) References
- The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid. | Coffey, DC., et al. 2001. Cancer Res. 61: 3591-4. PMID: 11325825
- The fibronectin type 3-like repeat from the Clostridium thermocellum cellobiohydrolase CbhA promotes hydrolysis of cellulose by modifying its surface. | Kataeva, IA., et al. 2002. Appl Environ Microbiol. 68: 4292-300. PMID: 12200278
- Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis. | Zhang, Y., et al. 2006. Cell Death Differ. 13: 129-40. PMID: 15947789
- CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells. | Takai, N., et al. 2006. Oncology. 70: 97-105. PMID: 16601366
Inhibitor of:
HDAC1, HDAC3, and neurocan.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBHA, 5 mg | sc-205240 | 5 mg | $132.00 | |||
CBHA, 25 mg | sc-205240A | 25 mg | $395.00 |