Caylin-1
Application:
Caylin-1 is an MDM2 inhibitor that induces apoptosis via the p53 pathway
Molecular Weight:
650.4
Molecular Formula:
C30H28Cl4N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
A nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, compound inhibits the growth of HCT-116 cells, making it less potent than nutlin-3 in the same assay. At concentrations at or below 1 µM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells.2
Caylin-1 References
1 Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).Inhibitor of:
MDM2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caylin-1, 1 mg | sc-223878 | 1 mg | $101.00 | |||
Caylin-1, 5 mg | sc-223878A | 5 mg | $338.00 |