Molecular structure of CAY10622, CAS Number: 1038549-25-5
CAY10622 (CAS 1038549-25-5)
Alternate Names:
3- [[[[[4- (aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]- N- (1, 2, 3, 4- tetrahydro- 7- isoquinolinyl)- benzamide
Application:
CAY10622 is CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases
CAS Number:
1038549-25-5
Molecular Weight:
443.5
Molecular Formula:
C25H25N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It was inactive (showing greater then 100-fold selectivity) against an additional 44 kinases evaluated.
CAY10622 (CAS 1038549-25-5) References
- A ROCK inhibitor permits survival of dissociated human embryonic stem cells. | Watanabe, K., et al. 2007. Nat Biotechnol. 25: 681-6. PMID: 17529971
- Applications for ROCK kinase inhibition. | Olson, MF. 2008. Curr Opin Cell Biol. 20: 242-8. PMID: 18282695
- Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. | Narumiya, S., et al. 2009. Cancer Metastasis Rev. 28: 65-76. PMID: 19160018
- Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. | Morwick, T., et al. 2010. J Med Chem. 53: 759-77. PMID: 20000469
- A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. | Lotz-Jenne, C., et al. 2016. Oncotarget. 7: 25983-6002. PMID: 27036020
- Dissecting the 17β-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer. | Fiocchetti, M., et al. 2018. J Cell Physiol. 233: 5087-5103. PMID: 29219195
- ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. | Esposito, D., et al. 2022. Nat Commun. 13: 703. PMID: 35121738
- A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. | Li, J., et al. 2022. NAR Genom Bioinform. 4: lqac065. PMID: 36110898
- A PI (3, 5) P2/ESCRT-III axis terminates STING signalling by facilitating TSG101-mediated lysosomal microautophagy[J]. | Taguchi T, Shoji T, Shinojima A. 2024: bioRxiv,. 2024.05. 26.: 595979.
Inhibitor of:
Rock, Rock-1, and Rock-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10622, 1 mg | sc-358882 | 1 mg | $95.00 | |||
CAY10622, 5 mg | sc-358882A | 5 mg | $350.00 |