CAY10594 CAS: 1130067-34-3
MF: C26H28N4O2
MW: 428.53
A PC-PLD2 inhibitor which also prevents the invasive migration of breast cancer cells.

CAY10594 (CAS 1130067-34-3)

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Synonym: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide
Application: A PC-PLD2 inhibitor which also prevents the invasive migration of breast cancer cells
CAS Number: 1130067-34-3
Molecular Weight: 428.53
Molecular Formula: C26H28N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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CAY10594 is a Phospholipase D (PLD) inhibitor. PLD is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD (PLD1 and PLD2) have been identified, with multiple splice variants of each. Although the two isoforms share functional and structural features, they are regulated differently and apparently serve distinct biological roles. CAY10594 is a potent PC-PLD2 inhibitor in vitro (IC50 = 140 nM). It also inhibits PC-PLD1 at higher concentrations (IC50 = 5.1 μM). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.


References

1. Scott, Sarah A., et al., 2009. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature chemical biology. 5(2): 108-17. PMID: 19136975

Physical State :
Solid
Solubility :
Soluble in DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:1 solution of DMSO: PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~756.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
PC-PLD2: IC50 = 110 nM (human); PC-PLD1: IC50 = 1 µM (human)
pK Values :
pKb: 9.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25105715
MDL Number :
MFCD18382100
SMILES :
C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4

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Certificate of Analysis

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CAY10594  Product Citations

See how others have used CAY10594. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29571767  Conde, MA. et al. 2018. Biochim. Biophys. Acta. 1863: 639-650.

Citations 1 to 1 of 1 total
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