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CAY10589 is an inhibitor of mPGES-1 (IC50 = 1.3 μM), 5-LO (IC50 = 1.0 μM), and PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 exhibits minor inhibition of Cox-1 and Cox-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.
1 Koeberle, A., Zettl, H., Greiner, C., et al. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. J Med Chem 51 8068-8076 (2008).
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