Molecular structure of CAY10526, CAS Number: 938069-71-7
CAY10526 (CAS 938069-71-7)
Alternate Names:
3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one
Application:
CAY10526 is an inhibitor of PGE2 production
CAS Number:
938069-71-7
Molecular Weight:
311.15
Molecular Formula:
C12H7BrO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 muM without any effect on COX-2 expression. CAY10526 is a ligand for Beta1 adrenergic receptors and can be used as a research tool to study protein interactions, receptor activation, and ion channels.
CAY10526 (CAS 938069-71-7) References
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- mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway. | Li, Y., et al. 2020. Cell Death Dis. 11: 221. PMID: 32251289
- Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels. | Chini, MG., et al. 2020. ACS Med Chem Lett. 11: 783-789. PMID: 32435385
- Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. | Reis, MB., et al. 2020. Nat Commun. 11: 5433. PMID: 33116136
- Triazol-phenyl Antipyretic Derivatives Inhibit mPGES-1 mRNA Levels in LPS-Induced RAW 264.7 Macrophage Cells. | Dos Santos, LD., et al. 2021. Antiinflamm Antiallergy Agents Med Chem. 20: 271-281. PMID: 33292158
- Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition. | Di Micco, S., et al. 2021. Front Chem. 9: 676631. PMID: 34046398
- Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis. | De Melo, P., et al. 2021. J Immunol. 207: 902-912. PMID: 34301845
- Growth of T-cell lymphoma cells is inhibited by mPGES-1/PGE2 suppression via JAK/STAT, TGF-β/Smad3 and PI3K/AKT signal pathways. | Li, Y., et al. 2022. Transl Cancer Res. 11: 2175-2184. PMID: 35966330
- Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes. | Osorio, EY., et al. 2023. PLoS Negl Trop Dis. 17: e0011040. PMID: 36630476
- Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease. | Kotsos, D. and Tziomalos, K. 2023. Int J Mol Sci. 24: PMID: 36769370
- Far upstream element-binding protein 1 confers lobaplatin resistance by transcriptionally activating PTGES and facilitating the arachidonic acid metabolic pathway in osteosarcoma. | Ma, Q., et al. 2023. MedComm (2020). 4: e257. PMID: 37180822
- 2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis. | Pan, B., et al. 2023. J Immunother Cancer. 11: PMID: 37316264
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10526, 1 mg | sc-223868 | 1 mg | $88.00 | |||
CAY10526, 5 mg | sc-223868A | 5 mg | $1029.00 |