Molecular structure of CAY10505, CAS Number: 1218777-13-9
CAY10505 (CAS 1218777-13-9)
Alternate Names:
(5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
Application:
CAY10505 is a PI3K inhibitor
CAS Number:
1218777-13-9
Molecular Weight:
289.28
Molecular Formula:
C14H8FNO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
CAY10505 is a potent PI3Kγ inhibitor with an IC50 of 30 nM. CAY10505 also prevents other α, β, and δ isoforms with IC50 values of 0.94, 20, and 20 μM, respectively. CAY10505 also inhibits casein kinase 2 (CK2, IC50 = 20 nM). CAY10505 suppresses the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM).
CAY10505 (CAS 1218777-13-9) References
- Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. | Pomel, V., et al. 2006. J Med Chem. 49: 3857-71. PMID: 16789742
- Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. | Tyagi, S., et al. 2012. Can J Physiol Pharmacol. 90: 881-5. PMID: 22731503
- Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. | Sun, YY., et al. 2013. PLoS One. 8: e69019. PMID: 23904909
- Isoform-Selective PI3K Inhibitors for Various Diseases. | Bheemanaboina, RRY. 2020. Curr Top Med Chem. 20: 1074-1092. PMID: 31903879
- MiR-1976 knockdown promotes epithelial-mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis. | Wang, J., et al. 2020. Cell Death Dis. 11: 500. PMID: 32620748
- Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice. | Ikegami, K. and Masubuchi, S. 2022. Commun Biol. 5: 339. PMID: 35396348
- Discovery of a novel phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor against hematologic malignancies and theoretical studies on its PI3Kγ-specific binding mechanisms. | Zhu, J., et al. 2019. RSC Adv. 9: 20207-20215. PMID: 35546906
- Circadian rhythm of intraocular pressure. | Ikegami, K. 2024. J Physiol Sci. 74: 14. PMID: 38431563
- Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases. | Huang, Q., et al. 2024. Sci Adv. 10: eadk1200. PMID: 38552012
- PI 3K‐dependent multiple myeloma cell survival is mediated by the PIK 3 CA isoform.' | Hofmann, Claudia,. (2014): British journal of haematology. 166.4: 529-539.
Inhibitor of:
GPR105, and PI 3-kinase.Activator of:
GPR55.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10505, 10 mg | sc-364456 | 10 mg | $80.00 | |||
CAY10505, 50 mg | sc-364456A | 50 mg | $280.00 |