CAY10500 (CAS 869998-49-2)
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CAY10500 is an inhibitor of tumor necrosis factor α (TNFα) that hinders its binding to TNF Receptor 1 (TNFR1). TNFα acts as a central mediator in various inflammatory conditions, including rheumatoid arthritis, toxic shock, and sepsis. Functioning as a trimer, TNFα facilitates receptor trimerization, which triggers proinflammatory and/or apoptotic signaling pathways. By binding to the biologically active TNFα trimer, CAY10500 accelerates the displacement of a single subunit, leading to the rapid inactivation of the cytokine. In a cell-based assay, CAY10500 effectively inhibited TNFα-induced stimulation of IKB degradation. Notably, both TNFα and the angiotensin II/angiotensin II receptor type 1 (AT1) axis play roles in neuropathic pain and nociception.
CAY10500 (CAS 869998-49-2) References
- Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. | Kochukov, MY., et al. 2009. Mol Pain. 5: 49. PMID: 19695100
- Is there a role of TNFR1 in acute lung injury cases associated with extracorporeal circulation? | Zhao, Y., et al. 2014. J Zhejiang Univ Sci B. 15: 281-8. PMID: 24599692
- Association between endothelin-1/endothelin receptor A and inflammation in mouse kidneys following acute ischemia/reperfusion. | Niu, J., et al. 2015. Mol Med Rep. 11: 3981-7. PMID: 25572710
- Differential Response of Neural Cells to Trauma-Induced Swelling In Vitro. | Jayakumar, AR., et al. 2018. Neurochem Res. 43: 397-406. PMID: 29150743
- IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice. | Mayordomo, AC., et al. 2018. PLoS One. 13: e0193573. PMID: 29494692
- Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior. | Chen, PY., et al. 2020. Biochem Pharmacol. 182: 114294. PMID: 33080184
- TNF-α signaling regulates RUNX1 function in endothelial cells. | Whitmore, HAB., et al. 2021. FASEB J. 35: e21155. PMID: 33135824
- The cooperative interplay among inflammation, necroptosis and YAP pathway contributes to the folate deficiency-induced liver cells enlargement. | Chi, WY., et al. 2022. Cell Mol Life Sci. 79: 397. PMID: 35790616
- Evaluating the Anticancer Activity of Blocking TNF Type 1 Receptors in Thioacetamide-Induced Hepatocellular Carcinoma in a Rat Model. | Bagalagel, A., et al. 2022. Cureus. 14: e32519. PMID: 36531792
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10500, 500 µg | sc-223865 | 500 µg | $78.00 | |||
CAY10500, 1 mg | sc-223865A | 1 mg | $193.00 | |||
CAY10500, 5 mg | sc-223865B | 5 mg | $287.00 | |||
CAY10500, 10 mg | sc-223865C | 10 mg | $500.00 |