Molecular structure of CAY10404, CAS Number: 340267-36-9
CAY10404 (CAS 340267-36-9)
See product citations (1)
Alternate Names:
3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole
Application:
CAY10404 is a selective inhibitors of COX-2
CAS Number:
340267-36-9
Molecular Weight:
367.34
Molecular Formula:
C17H12F3NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
One of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM, and COX-2 IC50 is
CAY10404 (CAS 340267-36-9) References
1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994). 2 Habeeb, A.G., Rao, P.N.P., Knaus, E.E. Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity. Drug Development Research 51 273-286 (2000). 3 Mardini, I.A., Fitzgerald, G.A. Selective inhibitors of cyclooxygenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1 30-38 (2001).Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY10404, 1 mg | sc-223860 | 1 mg | $36.00 | |||
CAY10404, 5 mg | sc-223860A | 5 mg | $162.00 |