Molecular structure of caspase-9 inhibitor I, CAS Number: 210345-04-3
caspase-9 inhibitor I (CAS 210345-04-3)
See product citations (33)
Alternate Names:
Z-LEHD-FMK Z-LE(OMe)HD(OMe)-FMK
Application:
caspase-9 inhibitor I is Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK
CAS Number:
210345-04-3
Purity:
≥95%
Molecular Weight:
690.72
Molecular Formula:
C32H43FN6O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A cell-permeable, and irreversible inhibitor of caspase-9 that may also inhibit caspase-4 and caspase-5 as well).
caspase-9 inhibitor I (CAS 210345-04-3) References
- Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. | Fadeel, B., et al. 1999. Leukemia. 13: 719-28. PMID: 10374876
- The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. | Ozoren, N., et al. 2000. Cancer Res. 60: 6259-65. PMID: 11103780
- Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. | Kashio, Y., et al. 2003. J Immunol. 170: 3631-6. PMID: 12646627
- Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. | Colak, A., et al. 2005. J Neurosurg Spine. 2: 327-34. PMID: 15796358
- Mechanism of caspase-3 activation during hypoxia in the cerebral cortex of newborn piglets. | Chiang, MC., et al. 2007. Neurosci Lett. 421: 67-71. PMID: 17553617
- Cell growth regulation through apoptosis by activin in human gastric cancer SNU-16 cell lines. | Kim, YI., et al. 2009. Oncol Rep. 21: 491-7. PMID: 19148527
- Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. | Bian, ZM., et al. 2009. Invest Ophthalmol Vis Sci. 50: 6006-14. PMID: 19643964
- Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. | Kim, BM. and Hong, SH. 2011. Apoptosis. 16: 184-97. PMID: 21107704
- Caspase-9 inhibitor Z-LEHD-FMK enhances the yield of in vitro produced buffalo (Bubalus bubalis) pre-implantation embryos and alters cellular stress response. | Mullani, N., et al. 2016. Res Vet Sci. 104: 4-9. PMID: 26850530
- Caspases: killer proteases. | Nicholson, DW. and Thornberry, NA. 1997. Trends Biochem Sci. 22: 299-306. PMID: 9270303
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
Inhibitor of:
caspase-4, caspase-5, caspase-9, CCRL2, Cdk7, Chemical and Peptide Caspase, CPP32 p11, ICE p20, LOC728369, Pdcd-7, Programmed cell death (PDCD), and Sp4.Activator of:
group III sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-9 inhibitor I, 1 mg | sc-3085 | 1 mg | $416.00 | |||
caspase-9 inhibitor I, 5 mg | sc-3085A | 5 mg | $1769.00 |