caspase-9 inhibitor I CAS: 210345-04-3
MF: C32H43FN6O10
MW: 690.72
Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK.

caspase-9 inhibitor I (CAS 210345-04-3)

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Alternate Names: Z-LEHD-FMK Z-LE(OMe)HD(OMe)-FMK
Application: caspase-9 inhibitor I is Cell-permeable derivative of caspase-4 inhibitor Z-LEVD-FMK
CAS Number: 210345-04-3
Purity: ≥95%
Molecular Weight: 690.72
Molecular Formula: C32H43FN6O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Caspase-9 inhibitor I (Z-LE(OMe)HD(OMe)-FMK) is a cell-permeable, and irreversible inhibitor of caspase-9 that may also inhibit caspase-4 and caspase-5 as well. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-6 Kit (sc-4266 AK).


References

1. Nicholson, D.W. and Thornberry, N.A. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22(8): 299-306. PMID: 9270303
2. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science. 281(5381): 1312-1316. PMID: 9721091
3. Fadeel, B., Hassan, Z., Hellström-Lindberg, E., Henter, J.I., Orrenius, S. and Zhivotovsky, B. 1999. Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia. 13(5): 719-728. PMID: 10374876
4. Bian, Z.M., Elner, S.G. and Elner, V.M. 2009. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 50(12): 6006-6014. PMID: 19643964

Usage :
• When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

• Recommended final working concentration: 50 nM to 100 μM. Investigator must establish the most
effective concentration for their particular assay.
• Following reconstitution, aliquot and freeze (-20°C); stable for up to 3 months at -20°C.
Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Z-Leu-Glu(O-Me)-His-Asp(O-Me)-FMK
Solubility :
Soluble in DMSO (20 mM).
Storage :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44135217
SMILES :
CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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caspase-9 inhibitor I (CAS 210345-04-3)  Product Citations

See how others have used caspase-9 inhibitor I (CAS 210345-04-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 32 total

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 30131570  Lee, BS.|Kim, YS.|Kim, HJ.|Kim, DH.|Won, HR.|Kim, YS.|Kim, CH.| et al. 2018. Sci Rep. 8: 12520.

PMID: # 27064569  2016. PLoS ONE. 11: e0151502.

PMID: # 25202081  Kim, EY. et al. 2014. Anticancer Res. 34: 4985-92.

PMID: # 23636812  2013. Biol. Reprod. 88: 149.

PMID: # 20727705  2010. Alcohol. 44: 553-63.

PMID: # 20500824  2010. J. Biomed. Sci. 17: 40.

PMID: # 20582477  2010. Apoptosis. 15: 1256-69.

PMID: # 20655907  2010. Eur. J. Pharmacol. 645: 14-22.

PMID: # 19358271  2009. Int. J. Cancer. 125: 222-8.

Citations 1 to 10 of 32 total
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