Molecular structure of Caspase-8 inhibitor II, CAS Number: 210344-98-2
Caspase-8 inhibitor II (CAS 210344-98-2)
See product citations (48)
Alternate Names:
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone; Z-IETD-FMK
Application:
Caspase-8 inhibitor II is a potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B
CAS Number:
210344-98-2
Purity:
≥98%
Molecular Weight:
654.68
Molecular Formula:
C30H43FN4O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Also inhibits influenza virus-induced apoptosis in HeLa cells.
Caspase-8 inhibitor II (CAS 210344-98-2) References
- Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. | Takizawa, T., et al. 1999. Microbiol Immunol. 43: 245-52. PMID: 10338194
- The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. | Ozoren, N., et al. 2000. Cancer Res. 60: 6259-65. PMID: 11103780
- z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. | Cowburn, AS., et al. 2005. Blood. 105: 2970-2. PMID: 15572588
- Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. | Kim, BM. and Hong, SH. 2011. Apoptosis. 16: 184-97. PMID: 21107704
- Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. | Lawrence, CP. and Chow, SC. 2012. Toxicol Appl Pharmacol. 265: 103-12. PMID: 22982538
- Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage. | Ke, DQ., et al. 2020. Neural Regen Res. 15: 1283-1289. PMID: 31960814
- Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation. | Lentini, G., et al. 2023. Cell Rep Med. 4: 101098. PMID: 37390829
- Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation. | Luk, CT., et al. 2023. Diabetes. 72: 1751-1765. PMID: 37699387
- Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. | Martin, DA., et al. 1998. J Biol Chem. 273: 4345-9. PMID: 9468483
- Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. | Sweeney, EA., et al. 1998. FEBS Lett. 425: 61-5. PMID: 9541007
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
Inhibitor of:
Apoptosis, caspase-10, caspase-13, caspase-8, caspase-9, Chemical and Peptide Caspase, CPP32 p11, DcR2, Enzyme, FLASH, granzyme B, MACHβ1, Pdcd-7, and Programmed cell death (PDCD).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-8 inhibitor II, 1 mg | sc-3084 | 1 mg | $285.00 | |||
Caspase-8 inhibitor II, 3 mg | sc-3084A | 3 mg | $612.00 |