You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Caspase-3 Inhibitor III (Ac-DEVD-CMK) is a potent cell-permeable and irreversible inhibitor of caspase-3, which is a member of the ICE-CED-3 family of cysteine proteases. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK). Caspase-3 Inhibitor III is an inhibitor of caspase-10, caspase-6, caspase-7 and caspase-8.
1. Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130: 197-200. PMID: 10807653
2. Schrantz, N., et al. 1999. Cell Death Differ. 6: 445-453. PMID: 10381635
3. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281: 1312-1316. PMID: 9721091
4. Zhang, Y., et al. 2004. J. Neurosc. 24: 10616-10627. PMID: 15564577
See how others have used Caspase-3 Inhibitor III. Click on the entry to view the PubMed entry .
PMID: # 25367763 Kliková, K. et al. 2015. General physiology and biophysics. 34: 33-42.
PMID: # 28436935 J. Clin. Invest. 127: 2222-2234.
PMID: # 29989100 Int. J. Biol. Sci. 14: 1099-1108.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.