Caspase-3 Inhibitor III (CAS 285570-60-7)
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Caspase-3 Inhibitor I also known as Ac-AAVALLPAVLLALLAPDEVD-cho is a cell-permeable inhibitor of caspase-3, caspase-6, caspase-7, caspase-8, and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. The C-terminal sequence of this peptide (DEVD-CHO) is a highly specific, potent, and reversible inhibitor of caspase-3 that also strongly inhibits PARP cleavage in cultured human osteosarcoma cell extracts. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).
Caspase-3 Inhibitor III (CAS 285570-60-7) References
- Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by bcl-2. | Schrantz, N., et al. 1999. Cell Death Differ. 6: 445-53. PMID: 10381635
- Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. | Mocanu, MM., et al. 2000. Br J Pharmacol. 130: 197-200. PMID: 10807653
- Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. | Zhang, Y., et al. 2004. J Neurosci. 24: 10616-27. PMID: 15564577
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-3 Inhibitor III, 1 mg | sc-300325 | 1 mg | $108.00 | |||
Caspase-3 Inhibitor III, 5 mg | sc-300325A | 5 mg | $414.00 |