Caspase-1 Inhibitor IV (CAS 154674-81-4)
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Caspase-1 Inhibitor IV (Ac-YVAD-AOM) is a highly selective, competitive and irreversible inhibitor of caspase-1, caspase-4 and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis. This product is an excellent candidate for studies of enzyme inhibition because it inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione.
Additional caspase-1 inhibitors available:
caspase-1 inhibitor (sc-3069)
caspase-1 inhibitor VI (sc-3071)
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor I (sc-358878)
Caspase-1 Inhibitor IV (CAS 154674-81-4) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-1 Inhibitor IV, 1 mg | sc-300324 | 1 mg | $184.00 |