Caspase-1 Inhibitor II (CAS 178603-78-6)
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Caspase-1 Inhibitor II (Ac-YVAD-CMK) is a cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. It also inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis. Additional caspase-1 inhibitors available: caspase-1 inhibitor (sc-3069) caspase-1 inhibitor VI (sc-3071) Caspase-1 Inhibitor IV (sc-300324) Caspase-1 Inhibitor I (sc-358878)
Caspase-1 Inhibitor II (CAS 178603-78-6) References
- Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. | Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. | Thornberry, NA., et al. 1992. Nature. 356: 768-74. PMID: 1574116
- Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model. | Wu, B., et al. 2010. Transl Stroke Res. 1: 57-64. PMID: 20596246
- AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage. | Lin, X., et al. 2018. Biomed Res Int. 2018: 3706047. PMID: 30410928
- Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes. | Qiu, Z., et al. 2019. J Diabetes Res. 2019: 8151836. PMID: 30911553
- Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. | Liang, H., et al. 2019. Int Immunopharmacol. 75: 105771. PMID: 31352322
- Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis. | Yang, M., et al. 2021. Biomed Res Int. 2021: 6636621. PMID: 34222479
- SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. | Pan, P., et al. 2021. Nat Commun. 12: 4664. PMID: 34341353
- Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment. | Zheng, D., et al. 2023. PLoS One. 18: e0280914. PMID: 36696410
- Involvement of an ICE-like protease in Fas-mediated apoptosis. | Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
- Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. | Walker, NP., et al. 1994. Cell. 78: 343-52. PMID: 8044845
- CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. | Schlegel, J., et al. 1996. J Biol Chem. 271: 1841-4. PMID: 8567626
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
- Inhibition of human caspases by peptide-based and macromolecular inhibitors. | Garcia-Calvo, M., et al. 1998. J Biol Chem. 273: 32608-13. PMID: 9829999
- Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. | Hilbi, H., et al. 1998. J Biol Chem. 273: 32895-900. PMID: 9830039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-1 Inhibitor II, 5 mg | sc-300323 | 5 mg | $255.00 | |||
Caspase-1 Inhibitor II, 25 mg | sc-300323A | 25 mg | $1224.00 |