Caspase-1 inhibitor I (CAS 143313-51-3)
See product citations (13)
QUICK LINKS
Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Caspase-1 Inhibitor I may act to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis. Additional caspase-1 inhibitors available: caspase-1 inhibitor (sc-3069) caspase-1 inhibitor VI (sc-3071) Caspase-1 Inhibitor II (sc-300323) Caspase-1 Inhibitor IV (sc-300324)
Caspase-1 inhibitor I (CAS 143313-51-3) References
- Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. | Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
- Depolarization and a NO-donor stimulate interleukin-1beta release from the rat hypothalamus via a mechanism involving caspase 1. | Tringali, G., et al. 1999. Neurosci Lett. 276: 119-22. PMID: 10624806
- Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins. | Schlosser, S., et al. 2001. FEBS Lett. 491: 104-8. PMID: 11226429
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. | Thornberry, NA., et al. 1992. Nature. 356: 768-74. PMID: 1574116
- TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner. | Grimstad, Ø., et al. 2013. J Dermatol Sci. 72: 45-53. PMID: 23845419
- NLRP3/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with lung cancer. | Lasithiotaki, I., et al. 2018. PLoS One. 13: e0205242. PMID: 30365491
- Involvement of an ICE-like protease in Fas-mediated apoptosis. | Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
- Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. | Walker, NP., et al. 1994. Cell. 78: 343-52. PMID: 8044845
- CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. | Schlegel, J., et al. 1996. J Biol Chem. 271: 1841-4. PMID: 8567626
- Dihydroheptaprenyl and dihydrodecaprenyl monophosphates induce apoptosis mediated by activation of caspase-3-like protease. | Yasugi, E., et al. 1998. Biochim Biophys Acta. 1389: 132-40. PMID: 9461254
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
- Inhibition of human caspases by peptide-based and macromolecular inhibitors. | Garcia-Calvo, M., et al. 1998. J Biol Chem. 273: 32608-13. PMID: 9829999
- Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. | Hilbi, H., et al. 1998. J Biol Chem. 273: 32895-900. PMID: 9830039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-1 inhibitor I, 1 mg | sc-358878 | 1 mg | $112.00 | |||
Caspase-1 inhibitor I, 5 mg | sc-358878A | 5 mg | $408.00 | |||
Caspase-1 inhibitor I, 10 mg | sc-358878B | 10 mg | $816.00 |