caspase-1 inhibitor
See product citations (1)
Alternate Names:
ICE Inhibitor I, Cell-permeable; Ac-AAVALLPAVLLALLAPYVAD-CHO
Application:
caspase-1 inhibitor is a cell-permeable inhibitor of caspase-1, caspase-4, and caspase-5
Purity:
≥95%
Molecular Weight:
1990.4
Molecular Formula:
C97H160N20O24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Cell-permeable inhibitor of caspase-1 (also known as ICE or Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal sequence (YVAD-CHO) of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal amino acid residues 1-16 correspond to the hydrophobic region of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confer cell-permeability to the peptide.
caspase-1 inhibitor References
- Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins. | Schlosser, S., et al. 2001. FEBS Lett. 491: 104-8. PMID: 11226429
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. | Thornberry, NA., et al. 1992. Nature. 356: 768-74. PMID: 1574116
- Developmental truncations of connexin 50 by caspases adaptively regulate gap junctions/hemichannels and protect lens cells against ultraviolet radiation. | Wang, K., et al. 2012. J Biol Chem. 287: 15786-97. PMID: 22418432
- Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis? | Orlowsky, EW., et al. 2014. BMC Musculoskelet Disord. 15: 318. PMID: 25261974
- Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. | Lin, YZ., et al. 1995. J Biol Chem. 270: 14255-8. PMID: 7782278
- Interleukin-1 beta converting enzyme. | Thornberry, NA. 1994. Methods Enzymol. 244: 615-31. PMID: 7845238
- Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones. | Thornberry, NA., et al. 1994. Biochemistry. 33: 3934-40. PMID: 8142397
- Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways. | Lin, YZ., et al. 1996. J Biol Chem. 271: 5305-8. PMID: 8621379
- Caspases: enemies within. | Thornberry, NA. and Lazebnik, Y. 1998. Science. 281: 1312-6. PMID: 9721091
- Inhibition of human caspases by peptide-based and macromolecular inhibitors. | Garcia-Calvo, M., et al. 1998. J Biol Chem. 273: 32608-13. PMID: 9829999
Inhibitor of:
caspase-1, caspase-4, caspase-5, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-1 inhibitor, 0.5 mg | sc-3069 | 0.5 mg | $228.00 |