Molecular structure of Casopitant mesylate, CAS Number: 414910-30-8
Casopitant mesylate (CAS 414910-30-8)
See product citations (1)
Alternate Names:
(2R,4S)-4-(4-Acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperidinecarboxamide Methanesulfonate
Application:
Casopitant mesylate is A tachykinin NK1 receptor antagonist
CAS Number:
414910-30-8
Molecular Weight:
712.72
Molecular Formula:
C30H35F7N4O2•CH4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Casopitant Mesylate is a novel tachykinin NK1 receptor antagonist. The binding of this compound to NK1 receptors inhibits the release of neurotransmitters and other mediators that are involved in the regulation of nausea and vomiting. Specifically, it may act to reduce the levels of the neurotransmitter serotonin and the neuropeptide substance P, as well as pro-inflammatory cytokines and chemokines. Casopitant Mesylate is studied for its anti-emetic and anti-inflammatory properties.
Casopitant mesylate (CAS 414910-30-8) References
- Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype. | Janicki, PK., et al. 2006. Anesth Analg. 102: 1127-33. PMID: 16551910
- Casopitant: a new warrior in the antiemetic crusade. | Khojasteh, A., et al. 2009. Expert Opin Pharmacother. 10: 1367-76. PMID: 19445564
- Randomized, double-blind, dose-ranging trial of the oral neurokinin-1 receptor antagonist casopitant mesylate for the prevention of cisplatin-induced nausea and vomiting. | Roila, F., et al. 2009. Ann Oncol. 20: 1867-73. PMID: 19541792
- Metabolic disposition of casopitant, a potent neurokinin-1 receptor antagonist, in mice, rats, and dogs. | Miraglia, L., et al. 2010. Drug Metab Dispos. 38: 1876-91. PMID: 20622044
- Quantitation of a de-fluorinated analogue of casopitant mesylate by normal-phase liquid chromatography/mass spectrometry. | Dams, R., et al. 2010. Rapid Commun Mass Spectrom. 24: 2650-4. PMID: 20740542
- NMR spectroscopy and surface tension measurements applied to the study of self-association of casopitant mesylate, a novel NK1 antagonist. | Provera, S., et al. 2011. J Pharm Biomed Anal. 54: 48-52. PMID: 20813479
- Detection, identification and quantification of a new de-fluorinated impurity in casopitant mesylate drug substance during late phase development: an analytical challenge involving a multidisciplinary approach. | Turco, L., et al. 2011. J Pharm Biomed Anal. 54: 67-73. PMID: 20813481
- The evaluation of drug rechallenge: the casopitant Phase III program. | Hunt, CM., et al. 2010. Regul Toxicol Pharmacol. 58: 539-43. PMID: 20932869
- Tissue distribution and characterization of drug-related material in rats and dogs after repeated oral administration of casopitant. | Pagliarusco, S., et al. 2011. Drug Metab Dispos. 39: 283-93. PMID: 20978104
- Casopitant and ondansetron for postoperative nausea and vomiting prevention in women at high risk for emesis: a phase 3 study. | Altorjay, A., et al. 2011. Arch Surg. 146: 201-6. PMID: 21339433
- A risk-based statistical investigation of the quantification of polymorphic purity of a pharmaceutical candidate by solid-state 19F NMR. | Barry, SJ., et al. 2012. Anal Chim Acta. 712: 30-6. PMID: 22177062
- Search for improved fluorinated stationary phases for separation of fluorine-containing pharmaceuticals from their desfluoro analogs. | Regalado, EL., et al. 2015. J Chromatogr A. 1380: 45-54. PMID: 25595532
- Ultrafast separation of fluorinated and desfluorinated pharmaceuticals using highly efficient and selective chiral selectors bonded to superficially porous particles. | Barhate, CL., et al. 2015. J Chromatogr A. 1426: 241-7. PMID: 26643720
- Neurokinin-1 inhibitors in the prevention of nausea and vomiting from highly emetogenic chemotherapy: a network meta-analysis. | Abdel-Rahman, O. 2016. Ther Adv Med Oncol. 8: 396-406. PMID: 27583032
Inhibitor of:
NK-1R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Casopitant mesylate, 1 mg | sc-214670 | 1 mg | $260.00 | |||
Casopitant mesylate, 5 mg | sc-214670B | 5 mg | $505.00 | |||
Casopitant mesylate, 10 mg | sc-214670A | 10 mg | $719.00 |