Molecular structure of Casein Kinase II Inhibitor III, TBCA, CAS Number: 934358-00-6
Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6)
See product citations (10)
Alternate Names:
(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
Application:
Casein Kinase II Inhibitor III, TBCA is a potent, cell-permeable Casein Kinase II inhibitor
CAS Number:
934358-00-6
Purity:
>95%
Molecular Weight:
463.8
Molecular Formula:
C9H4Br4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Casein Kinase II Inhibitor III, TBCA is a cell-permeable serine/ threonine kinase that is a tetrabrominated cinnamic acid compound. Casein Kinase II Inhibitor III, TBCA acts as an ATP-competitive and potent inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than DMAT and TBB (sc-202830) against a panel of 28 commonly studied kinases. Studies show that it induces apoptosis in Jurkat cells (DC50 = 7.7 µM) more efficiently than DMAT.
Casein Kinase II Inhibitor III, TBCA (CAS 934358-00-6) References
- Protein kinase CK2: a newcomer in the 'druggable kinome'. | Pagano, MA., et al. 2006. Biochem Soc Trans. 34: 1303-6. PMID: 17073807
- Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. | Pagano, MA., et al. 2007. Chembiochem. 8: 129-39. PMID: 17133643
- New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. | López-Ramos, M., et al. 2010. FASEB J. 24: 3171-85. PMID: 20400536
- Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer. | Zhang, Y., et al. 2012. J Biol Chem. 287: 32494-511. PMID: 22854964
- Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function. | Qaiser, F., et al. 2014. J Cell Biochem. 115: 2103-15. PMID: 25043911
- Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA. | Wei, TW., et al. 2017. Cancer Res. 77: 494-508. PMID: 28069801
- Small molecule screen in embryonic zebrafish using modular variations to target segmentation. | Richter, S., et al. 2017. Nat Commun. 8: 1901. PMID: 29196645
- Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse. | Qiang, L., et al. 2019. Hum Mol Genet. 28: 1136-1152. PMID: 30520996
- A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression. | Lee, K., et al. 2020. Oncogenesis. 9: 2. PMID: 31900384
Inhibitor of:
ARHGEF39, ARL7, Casein Kinase, FAM109A, Rab 11A, and Ser/Thr Protein Kinase.Activator of:
9430069J07Rik, NMUR1, parathymosin, and V1RC2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Casein Kinase II Inhibitor III, TBCA, 5 mg | sc-203869 | 5 mg | $197.00 |