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A cell-permeable pyrimidine compound which potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC50= 100 nM) without significant cytotoxic effect, even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is way more efficient than that achieved by EBs (embryoid bodies) formation and DMSO treatment.
Wu, X., et al. 2004. J. Am. Chem. Soc. 126, 1590.
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