(Carboxymethyloximino)spiperone, Hemihydrate (CAS 355012-90-7)
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(Carboxymethyloximino)spiperone, Hemihydrate is used as an affinity chromatography matrix support for the purification of the D2-dopamine receptor. Spiperone (sc-204293) is an 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Although the well known role of Spiperone in research studies indicates it acts as an antagonist of either 5-HT2 or D2 receptors, Spiperone has also been reported to act through a protein tyrosine kinase-coupled phospholipase C-dependent pathway. Spiperone was observed to act independent of either 5-HT2 or D2 receptors as reported In a study investigating the role of Spiperone and Ca2+ activated Cl- (CaCC) in human cystic fibrosis (CF) airway epithelial cell monolayers in vitro.
(Carboxymethyloximino)spiperone, Hemihydrate (CAS 355012-90-7) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(Carboxymethyloximino)spiperone, Hemihydrate, 10 mg | sc-211021 | 10 mg | $430.00 |