Date published: 2025-10-20

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Carboxymethyl chitosan (CAS 83512-85-0)

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Application:
Carboxymethyl chitosan is a carbohydrate polysaccharide chitosan derivative
CAS Number:
83512-85-0
Purity:
Deacetylation degree 90%
Molecular Formula:
(C8H14NO6)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Carboxymethyl chitosan (CMC) is a carbohydrate polysaccharide. It is an important water-soluble chitosan derivative with many attractive chemical, physical and biological properties. Carboxymethyl chitosan is an efficient metal chelator and exhibits high adsorption capacities for dyes. It also displays antimicrobial, anticancer, antitumor, antioxidant, and antifungal biological activities in various areas such as wound healing, tissue engineering, drug/enzyme delivery, bioimaging, and cosmetics.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences


Carboxymethyl chitosan (CAS 83512-85-0) References

  1. Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices.  |  Chen, L., et al. 2004. Biomaterials. 25: 3725-32. PMID: 15020148
  2. Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation.  |  Ge, HC. and Luo, DK. 2005. Carbohydr Res. 340: 1351-6. PMID: 15854605
  3. The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan.  |  Guo, Z., et al. 2005. Bioorg Med Chem Lett. 15: 4600-3. PMID: 16122924
  4. Carboxymethyl chitosan as a matrix material for platinum, gold, and silver nanoparticles.  |  Laudenslager, MJ., et al. 2008. Biomacromolecules. 9: 2682-5. PMID: 18816099
  5. Antimicrobial activity of hydroxylbenzenesulfonailides derivatives of chitosan, chitosan sulfates and carboxymethyl chitosan.  |  Zhong, Z., et al. 2009. Int J Biol Macromol. 45: 163-8. PMID: 19414029
  6. Effects of carboxymethyl chitosan on the blood system of rats.  |  Fu, D., et al. 2011. Biochem Biophys Res Commun. 408: 110-4. PMID: 21463605
  7. Effect of chitosan and carboxymethyl chitosan on fibrinogen structure and blood coagulation.  |  Zhang, W., et al. 2013. J Biomater Sci Polym Ed. 24: 1549-63. PMID: 23848448
  8. Preparation, characterization and antioxidant activity of phenolic acids grafted carboxymethyl chitosan.  |  Liu, J., et al. 2013. Int J Biol Macromol. 62: 85-93. PMID: 23994782
  9. The implications of recent advances in carboxymethyl chitosan based targeted drug delivery and tissue engineering applications.  |  Upadhyaya, L., et al. 2014. J Control Release. 186: 54-87. PMID: 24806482
  10. Synthesis and antioxidant properties of chitosan and carboxymethyl chitosan-stabilized selenium nanoparticles.  |  Chen, W., et al. 2015. Carbohydr Polym. 132: 574-81. PMID: 26256384
  11. Optimization of carboxymethyl chitosan synthesis using response surface methodology and desirability function.  |  Bukzem, AL., et al. 2016. Int J Biol Macromol. 85: 615-24. PMID: 26778157
  12. Cytocompatible quaternized carboxymethyl chitosan/poly(vinyl alcohol) blend film loaded copper for antibacterial application.  |  Yin, M., et al. 2018. Int J Biol Macromol. 120: 992-998. PMID: 30176325
  13. Edible coating based on beeswax-in-water Pickering emulsion stabilized by cellulose nanofibrils and carboxymethyl chitosan.  |  Xie, B., et al. 2020. Food Chem. 331: 127108. PMID: 32593036
  14. Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights.  |  Chaiwong, N., et al. 2020. Polymers (Basel). 12: PMID: 32605198
  15. Comparative studies of chitosan and carboxymethyl chitosan doped with nickel and copper: Characterization and antibacterial potential.  |  Olanipekun, EO., et al. 2021. Int J Biol Macromol. 183: 1971-1977. PMID: 34052274

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Carboxymethyl chitosan, 25 g

sc-358091
25 g
$108.00

Carboxymethyl chitosan, 100 g

sc-358091A
100 g
$315.00

How many monomer units are there in this 25gms of CMCs

Asked by: Priya29
Thank you for your question. The molecular weight of polymers ranges between 50000 and 100000.
Answered by: Tech Support Europe
Date published: 2024-12-18

Hi, is this O-carboxymethyl chitosan? because I need carboxymethyl chitosan with free amine groups. best regards, Sara

Asked by: Sara
Thank you for your question. This compound is supplied as O-caboxymethyl chitosan. >80% of amino groups are retained.
Answered by: Tech Support Europe
Date published: 2024-09-05

Is this a salt with a counter ion, like sodium. -or is the structure as shown in the picture?

Asked by: DFM123
Thank you for your question. The reagent will be the same as the structure on the webpage.
Answered by: BlakeJ
Date published: 2023-06-16

I used the GPC to determine the molecular but it’s below 100kDa, but it’s not between 100kDa-300kDa that you answer under the question before. So I wonder what is actually the molecular weight of carboxymethyl chitosan?

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2024-08-18

Please , what is the molecular weight of carboxymethyl chitosan?

Asked by: Dr Asmaa Elhoussiny
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2023-12-11

I only see the deacylation degree of this product, but this is the main parameter to describe the chitosan product. in terms of the carboxymethyl chitosan, what is the degree of carboxymethylation?

Asked by: Cedric210212912912
Thank you for your question! Please contact our technical service team directly for a certificate of analysis of the latest batch of this compound.
Answered by: Tech Support Europe
Date published: 2023-06-06

Is this carboxymethyl chitosan antibacterial?

Asked by: xyh001
Thank you for your question. There are online sources that suggest this but we have not tested or studied the antibacterial activity of this compound. Please contact our Asia Technical Support team for additional information. You may reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com.
Answered by: Santa Cruz TS
Date published: 2021-07-07

Is this product (Carboxymethyl chitosan: sc-358091) USP or EP grade? Can I buy medical grade Carboxymethyl chitosan?

Asked by: ph1205
Thank you for your question. All of our products are of research grade quality and are not suitable for medical applications.
Answered by: Technical Support Europe
Date published: 2022-02-16
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Rated 5 out of 5 by from Michelino Di Rosa; et alMichelino Di Rosa; et al. (PubMed ID: 24440516) demonstrated that Carboxymethyl chitosan decreased CHIT1 activity in Osteoclasts. -SCBT Publication Review
Date published: 2015-06-07
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Carboxymethyl chitosan is rated 5.0 out of 5 by 1.
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