(−)-Carbovir-5-triphosphate Triethylammonium Salt
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(−)-Carbovir-5′-triphosphate is a nucleoside reverse transcriptase inhibitor that functions by competitively inhibiting the incorporation of deoxynucleoside triphosphates into viral DNA by HIV-1 reverse transcriptase. (−)-Carbovir-5′-Triphosphate acts as a chain terminator, preventing the elongation of the viral DNA strand and ultimately inhibiting viral replication. By mimicking the structure of nucleotides, (−)-Carbovir-5′-triphosphate is able to effectively interfere with the reverse transcription process, disrupting the synthesis of viral DNA. (−)-Carbovir-5′-Triphosphate targets the catalytic site of HIV-1 reverse transcriptase, interfering with the enzyme′s ability to accurately replicate the viral genome. As a result, (−)-Carbovir-5′-triphosphate plays a key role in inhibiting the replication of HIV-1, making it useful for studying the molecular mechanisms of viral replication and for developing a deeper understanding of HIV pathogenesis.
(−)-Carbovir-5-triphosphate Triethylammonium Salt References
- Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells. | Parker, WB., et al. 2000. Nucleosides Nucleotides Nucleic Acids. 19: 795-804. PMID: 10960036
- Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels. | Balzarini, J., et al. 2004. FEBS Lett. 573: 38-44. PMID: 15327972
- Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects. | Jackson, A., et al. 2012. Antivir Ther. 17: 19-24. PMID: 22267465
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Carbovir-5-triphosphate Triethylammonium Salt, 1 mg | sc-504659 | 1 mg | $810.00 |