Date published: 2026-4-24

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Carboplatin-d4 (CAS 41575-94-4 (unlabeled))

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Alternate Names:
(SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum; cis-Diammine(1,1-cyclobutane-d4-dicarboxylato)platinum(II);
Application:
Carboplatin-d4 is deuterated Carboplatin, an anti-neoplastic agent with lower nephrotoxicity than Cisplatin
CAS Number:
41575-94-4 (unlabeled)
Purity:
98%
Molecular Weight:
375.27
Molecular Formula:
C6H8D4N2O4Pt
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Carboplatin-d4 is a labeled derivative of Carboplatin (sc-202093), a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of anti-neoplastic agents. Carboplatin displays potent antiproliferative activity and lower nephrotoxicity than Cisplatin. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


Carboplatin-d4 (CAS 41575-94-4 (unlabeled)) References

  1. What is the 'best' platinum: cisplatin, carboplatin, or oxaliplatin?  |  Lokich, J. 2001. Cancer Invest. 19: 756-60. PMID: 11577818
  2. Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.  |  Ito, H., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 917-918: 18-23. PMID: 23348368
  3. Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry: An Attractive and Prospective Method for the Quantitative Bioanalysis in Drug Metabolism.  |  Li, Z., et al. 2016. Curr Drug Metab. 17: 386-400. PMID: 26651973
  4. Carboplatin: a very active new cisplatin analog in the treatment of small cell lung cancer.  |  Smith, IE., et al. 1985. Cancer Treat Rep. 69: 43-6. PMID: 2981620
  5. Carboplatin (JM8) as a single agent and in combination in the treatment of small cell lung cancer.  |  Smith, IE. and Evans, BD. 1985. Cancer Treat Rev. 12 Suppl A: 73-5. PMID: 3002624
  6. Systemic Evaluation on the Pharmacokinetics of Platinum-Based Anticancer Drugs From Animal to Cell Level: Based on Total Platinum and Intact Drugs.  |  Qin, Z., et al. 2019. Front Pharmacol. 10: 1485. PMID: 31969818
  7. Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure ‒ assessment in a novel porcine model.  |  Petersen, EK., et al. 2022. Pleura Peritoneum. 7: 117-125. PMID: 36159212
  8. Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function.  |  Harland, SJ., et al. 1984. Cancer Res. 44: 1693-7. PMID: 6367971

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Carboplatin-d4, 1 mg

sc-217840
1 mg
$388.00