Molecular structure of Carbetapentane, CAS Number: 77-23-6
Carbetapentane (CAS 77-23-6)
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Alternate Names:
Pentoxyverine
Application:
Carbetapentane is an antitussive anticonvulsant sigma site agonist
CAS Number:
77-23-6
Purity:
≥98%
Molecular Weight:
333.47
Molecular Formula:
C20H31NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Carbetapentane is a non-opiod small molecule agonist of sigma sites, producing antitussive and anticonvulsant effects. Carbetapentane is described to protect rats against maximal electroshock-induced seizures. A study demonstrates that the attenuation of kainic acid-induced neurotoxicity by Carbetapentane is overriden by a sigma-1 receptor antagonist, indicating that Carbetapentane produces neuroprotection through its sigma site binding activity. Binding activity on muscarinic receptors is also reported, though Carbetapentane did not provide protection against NMDA lethality and therefore does not demonstrate the NMDA-antagonist action ascribed to the closely related antitussive and anticonvulsant Dextromethorphan (sc-204716).
Carbetapentane (CAS 77-23-6) References
- Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation. | Kim, HC., et al. 2001. Life Sci. 69: 915-22. PMID: 11488404
- M1 muscarinic antagonists interact with sigma recognition sites. | Hudkins, RL. and DeHaven-Hudkins, DL. 1991. Life Sci. 49: 1229-35. PMID: 1658507
- Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands. | Rothman, RB., et al. 1991. Mol Pharmacol. 39: 222-32. PMID: 1847495
- Modulators of N-methyl-D-aspartate protect against diazepam- or phenobarbital-resistant cocaine convulsions. | Witkin, JM. and Tortella, FC. 1991. Life Sci. 48: PL51-6. PMID: 1847729
- Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents. | Calderon, SN., et al. 1991. J Med Chem. 34: 3159-64. PMID: 1956032
- Cutaneous analgesia and systemic toxicity of carbetapentane and caramiphen in rats. | Hung, CH., et al. 2012. Reg Anesth Pain Med. 37: 34-9. PMID: 22157742
- Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons. | White, SH., et al. 2012. J Neurophysiol. 107: 2083-95. PMID: 22279188
- The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents. | Leung, YM., et al. 2013. Eur J Pharmacol. 714: 366-72. PMID: 23872380
- Evaluation of dextromethorphan and carbetapentane as anticonvulsants and N-methyl-D-aspartic acid antagonists in mice. | Leander, JD. 1989. Epilepsy Res. 4: 28-33. PMID: 2666123
- Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties. | Tortella, FC. and Musacchio, JM. 1986. Brain Res. 383: 314-8. PMID: 3768695
- Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane. | Wallace, DR. and Booze, RM. 1995. J Neurochem. 64: 700-10. PMID: 7830063
- Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. | Calderon, SN., et al. 1994. J Med Chem. 37: 2285-91. PMID: 8057277
- Discriminative stimulus properties of dextromethorphan in rats. | Gavend, M., et al. 1995. Biomed Pharmacother. 49: 456-64. PMID: 8746072
Inhibitor of:
KOR-3.Activator of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carbetapentane, 100 mg | sc-201100 | 100 mg | $300.00 | |||
Carbetapentane, 500 mg | sc-201100A | 500 mg | $400.00 |