Molecular structure of Carbacyclin (Carbocyclic PGI2), CAS Number: 69552-46-1
Carbacyclin (Carbocyclic PGI2) (CAS 69552-46-1)
See product citations (8)
Alternate Names:
cPGI; Carbaprostacyclin
Application:
Carbacyclin (Carbocyclic PGI2) is a stable analog of prostacyclin that inhibits platelet aggregation
CAS Number:
69552-46-1
Purity:
>99%
Molecular Weight:
350.49
Molecular Formula:
C21H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Carbacyclin (Carbocyclic PGI2) is a stable prostacyclin analog found to inhibit platelet aggregation induced by collagen or ADP. In experiments shown to reduce systemic arterial blood pressure in various animals. Displays ability to relax bovine coronary arteries and human respiratory smooth muscles. Also evident to act as an effector for preadipose cell differentiation. Very useful mimic of prostacyclin with lower potency. Suggested to be an IP Receptor and PPARbeta activator.
Carbacyclin (Carbocyclic PGI,[object Object],) (CAS 69552-46-1) References
- Influence of aspirin and carbacyclin on bovine platelet function. | Rao, GH., et al. 1992. ASAIO J. 38: 830-4. PMID: 1450481
- Fully stereocontrolled syntheses of 3-oxacarbacyclin and carbacyclin by the conjugate addition-azoalkene-asymmetric olefination strategy. | Kim, M. and Gais, HJ. 2006. J Org Chem. 71: 4642-50. PMID: 16749799
- Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway. | Kuroda, T., et al. 2007. J Mol Cell Cardiol. 43: 54-62. PMID: 17540403
- Stereocontrolled synthesis of exocyclic olefins using arene tricarbonyl chromium complex-catalyzed hydrogenation. I. Efficient synthesis of carbacyclin and its analogs. | Sodeoka, M., et al. 1991. Chem Pharm Bull (Tokyo). 39: 309-22. PMID: 2054856
- Trans-placental transport and metabolism of carbacyclin by perfused human placental in vitro. | Walenga, RW., et al. 1989. Prostaglandins. 37: 121-34. PMID: 2655009
- Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | Hamid, S. and Whittle, BJ. 1985. Br J Pharmacol. 85: 285-90. PMID: 2992652
- Inhibition of tumor cell induced platelet aggregation by prostacyclin and carbacyclin: an ultrastructural study. | Menter, DG., et al. 1987. Invasion Metastasis. 7: 109-28. PMID: 3294727
- A comparison of the inhibitory effects of prostacyclin and carbacyclin on platelet adhesion to collagen. | Karniguian, A., et al. 1982. Prostaglandins. 24: 827-36. PMID: 6300971
- The effect of carbacyclin, a prostaglandin analogue, on adenylate cyclase activity in platelet membranes. | Stein, JM. and Martin, BR. 1984. FEBS Lett. 165: 290-2. PMID: 6363123
- Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation. | Whittle, BJ., et al. 1980. Prostaglandins. 19: 605-27. PMID: 6992234
- Comparison in anesthetized dogs of the anti-aggregatory and hemodynamic effects of prostacyclin and a chemically stable prostacyclin analog, 6a-carba-PGI2 (carbacyclin). | Aiken, JW. and Shebuski, RJ. 1980. Prostaglandins. 19: 629-43. PMID: 6992235
- Platelet and other effects of carboprostacyclin--a stable prostacyclin analogue. | Adaikan, PG., et al. 1980. Prostaglandins Med. 5: 307-20. PMID: 7003626
- FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships. | Takasuka, M., et al. 1994. J Med Chem. 37: 47-56. PMID: 8289201
- The prostacyclin analogue carbacyclin inhibits Ca(2+)-activated K+ current in aortic baroreceptor neurones of rats. | Li, Z., et al. 1997. J Physiol. 501 (Pt 2): 275-87. PMID: 9192300
Activator of:
DP, IP Receptor, and PPAR beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carbacyclin (Carbocyclic PGI2), 1 mg | sc-201250 | 1 mg | $350.00 | |||
Carbacyclin (Carbocyclic PGI2), 5 mg | sc-201250A | 5 mg | $970.00 |