Molecular structure of Captopril, CAS Number: 62571-86-2
Captopril (CAS 62571-86-2)
See product citations (21)
Alternate Names:
Capoten;L-Captopril
Application:
Captopril is a competitive inhibitor of LTA4 hydrolase and other enzymes
CAS Number:
62571-86-2
Purity:
≥98%
Molecular Weight:
217.28
Molecular Formula:
C9H15NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H IC50 = 11muM). Captopril may act to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.
Captopril (CAS 62571-86-2) References
- Aspirin renography in the diagnosis of renovascular hypertension: a comparative study with captopril renography. | Maini, A., et al. 2000. Nucl Med Commun. 21: 325-31. PMID: 10845220
- Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse. | Emanueli, C., et al. 2000. Br J Pharmacol. 130: 1076-82. PMID: 10882392
- A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. | Tipnis, SR., et al. 2000. J Biol Chem. 275: 33238-43. PMID: 10924499
- Effects of ACE-inhibitors on learning and memory processes in rats. | Nikolova, JG., et al. 2000. Folia Med (Plovdiv). 42: 47-51. PMID: 10979177
- Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients. | Conlin, PR., et al. 2000. Hypertension. 36: 461-5. PMID: 10988282
- Effect of captopril on serum angiotensin converting enzyme and blood pressure in hypertensive patients. | Singh, R., et al. 1996. J Assoc Physicians India. 44: 109-11. PMID: 10999062
- Comparison of losartan and captopril in ELITE II. | Lye, M. 2000. Lancet. 356: 852; author reply 852-3. PMID: 11022949
- Effect of angiotensin-converting enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPP) randomized trial. The Captopril Prevention Project (CAPP) Study Group. | . 1999. Curr Hypertens Rep. 1: 466-7. PMID: 11041675
- Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure. | Gavras, H. and Brunner, HR. 2001. Hypertension. 37: 342-5. PMID: 11230297
- Renal implications of angiotensin receptor blockers. | Hollenberg, NK. 2001. Am J Hypertens. 14: 237S-241S. PMID: 11459212
- Microvascular angiogenesis and the renin-angiotensin system. | Greene, AS. and Amaral, SL. 2002. Curr Hypertens Rep. 4: 56-62. PMID: 11790293
- Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. | Kim, YJ. and Uyama, H. 2005. Cell Mol Life Sci. 62: 1707-23. PMID: 15968468
- Antihypertensive effects of verapamil, captopril and their combination at rest and during dynamic exercise. | Di Somma, S., et al. 1992. Arzneimittelforschung. 42: 103-7. PMID: 1610414
- Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. | Orning, L., et al. 1991. J Biol Chem. 266: 16507-11. PMID: 1885582
- Influence of captopril on glucose and fatty acid oxidation in human thrombocytes and mononuclear leucocytes. | Haeckel, R. and Colic, D. 1991. Arzneimittelforschung. 41: 37-9. PMID: 1904726
- Angiotensin converting enzyme inhibitors. II. Clinical use. | Kostis, JB. 1988. Am Heart J. 116: 1591-605. PMID: 3057846
- Inhibition of angiotensin converting enzyme: mechanism and substrate dependence. | Shapiro, R. and Riordan, JF. 1984. Biochemistry. 23: 5225-33. PMID: 6095893
- Effects of furosemide, captopril and indometacin on the renin-angiotensin system and the renal prostaglandins in anesthetized neonatal piglets. | Joppich, R., et al. 1995. Arzneimittelforschung. 45: 822-5. PMID: 8573231
- Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). | Zhang, L., et al. 1996. Clin Exp Hypertens. 18: 201-26. PMID: 8869001
- Captopril renal scintigraphy in renovascular hypertension. | Khairullah, QT., et al. 1997. Am Fam Physician. 55: 2240-4. PMID: 9149651
Inhibitor of:
ACE, Ace3, AGT1, AGTRAP, Aminopeptidase B-L1, Aminopeptidase P2, Aminopeptidase P3, AMZ1, ANG III, Angiotensinase C, ANKS6, ARG-Vasopressin, arginase II, ATP1B3, BPIL1, C2orf89, carboxypeptidase B2 (TAFI), CCP4, ChM-I, Chr-A, CNDP2, Collagen Type IV, CPXM2, CTRL, DGCR14, Dispase I, DMWD, Doxl2, DPEP1, Elmo3, ENGase, Enzyme, ES, Fibrocystin, FIZ1, Gm13718, GST, HRASLS, JAM (junction adhesion molecule), kallistatin, Kininogen I, Klkb16, laeverin_4833403I15Rik, Leukotriene A4 hydrolase, LMLN, LTA4H, MAS1, Metallothionein 3, murinoglobulin 1, NAALAD2, NAALADL2, NKAIN1, Norpeg, Olfr344, Olfr936, Olr1470, Olr1511, Olr192, Olr211, Olr222, Olr34, Olr400, Olr437, OMG, PEPD, PEPT1, phospholemman, pilD, SUDD, tPA, vanin-2, Vmn2r65, Vmn2r67, and YadA.Activator of:
Ace3, Aminopeptidase P, ANG III, ANG IV, ATP13A3, bradykinin, CAT-3, CPA4, CPD, IRAP, KCNG1, KCNG2, Kininogen, KLHL3, KLK1_Klk1, KLK13, LRFN5, Meprin A, MetAP-1, Na+ CP type IIIβ, NCCT, NPEPL1, PEPT2, Relaxin 1, Renin, Renin-1, RhCE, TNNI3K, and V3R 11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Captopril, 1 g | sc-200566 | 1 g | $49.00 | |||
Captopril, 5 g | sc-200566A | 5 g | $91.00 |