Candicidin (CAS 1403-17-4)
CAS Number:
1403-17-4
Molecular Weight:
1109.3
Molecular Formula:
C59H84N2O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Candicidin is a polyene antifungal antibiotic produced. Candicidin is a member of the macrolide family of antibiotics and is known for its ability to disrupt the integrity of fungal cell membranes by binding to ergosterol, a key component of the fungal cell membrane. This binding leads to the formation of pores in the membrane, ultimately causing leakage of cellular contents and cell death. Candicidin is effective against a wide range of pathogenic fungi, including Candida species.
Candicidin (CAS 1403-17-4) References
- Candicidin biosynthesis in Streptomyces griseus. | Gil, JA. and Campelo-Diez, AB. 2003. Appl Microbiol Biotechnol. 60: 633-42. PMID: 12664141
- Candicidin biosynthesis gene cluster is widely distributed among Streptomyces spp. isolated from the sediments and the neuston layer of the Trondheim fjord, Norway. | Jørgensen, H., et al. 2009. Appl Environ Microbiol. 75: 3296-303. PMID: 19286787
- Enzymology of the polyenes pimaricin and candicidin biosynthesis. | Martín, JF. and Aparicio, JF. 2009. Methods Enzymol. 459: 215-42. PMID: 19362642
- The stereostructure of candicidin D. | Szwarc, K., et al. 2015. J Antibiot (Tokyo). 68: 504-10. PMID: 25712395
- Coordinate Regulation of Antimycin and Candicidin Biosynthesis. | McLean, TC., et al. 2016. mSphere. 1: PMID: 27981234
- Enhancing candicidin biosynthesis by medium optimization and pH stepwise control strategy with process metabolomics analysis of Streptomyces ZYJ-6. | Liu, X., et al. 2018. Bioprocess Biosyst Eng. 41: 1743-1755. PMID: 30132081
- Dynamic changes of metabolomics and expression of candicidin biosynthesis gene cluster caused by the presence of a pleiotropic regulator AdpA in Streptomyces ZYJ-6. | Liu, X., et al. 2019. Bioprocess Biosyst Eng. 42: 1353-1365. PMID: 31062087
- A Hierarchical Network of Four Regulatory Genes Controlling Production of the Polyene Antibiotic Candicidin in Streptomyces sp. Strain FR-008. | Zhu, Y., et al. 2020. Appl Environ Microbiol. 86: PMID: 32086301
- Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68. | Yao, X., et al. 2021. Appl Environ Microbiol. 87: PMID: 33608297
- The polyene antifungal candicidin is selectively packaged into membrane vesicles in Streptomyces S4. | Blackburn, SA., et al. 2022. Arch Microbiol. 204: 289. PMID: 35488016
- Candicidin and other polyenic antifungal antibiotics. | Waksman, SA., et al. 1965. Bull World Health Organ. 33: 219-26. PMID: 5320588
- Factors affecting the production of candicidin. | Liu, DM., et al. 1975. Antimicrob Agents Chemother. 7: 196-202. PMID: 806261
- Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin. | Martin, JF. and Mcdaniel, LE. 1975. Biochim Biophys Acta. 411: 186-94. PMID: 811262
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Candicidin, 1 mg | sc-504601 | 1 mg | $572.00 |