Candesartan-d4 (CAS 1346604-70-3)
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Candesartan-d4 is a deuterated form of candesartan, is an angiotensin II receptor blocker (ARB). In this deuterated variant, four hydrogen atoms are replaced with deuterium (^2H or D), a stable hydrogen isotope. This subtle modification significantly enhances the compound′s utility in pharmacological and biochemical research, particularly for studies focused on drug metabolism, pharmacokinetics, and the elucidation of drug-receptor interaction mechanisms. The presence of deuterium atoms does not substantially alter the pharmacological profile of candesartan, but it allows for precise tracking and analysis of the drug within biological systems using techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Candesartan-d4 (CAS 1346604-70-3) References
- Determination of Candesartan in Human Plasma with Liquid Chromatography - Tandem Mass Spectrometry. | Forjan, V., et al. 2016. Acta Chim Slov. 63: 38-46. PMID: 26970787
- Pharmacokinetic and Bioequivalence Studies of a Newly Developed Branded Generic of Candesartan Cilexetil Tablets in Healthy Volunteers. | Patel, R., et al. 2017. Clin Pharmacol Drug Dev. 6: 492-498. PMID: 27753282
- The simultaneous UPLC-MS/MS determination of emerging drug combination; candesartan and chlorthalidone in human plasma and its application. | Patel, B., et al. 2017. Biomed Chromatogr. 31: PMID: 28178366
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Candesartan-d4, 1 mg | sc-504603 | 1 mg | $480.00 |