Molecular structure of Camostat mesylate, CAS Number: 59721-29-8
Camostat mesylate (CAS 59721-29-8)
See product citations (5)
Alternate Names:
camostat mesilate
Application:
Camostat mesylate is a protease and Trypsin inhibitor
CAS Number:
59721-29-8
Purity:
>98%
Molecular Weight:
494.52
Molecular Formula:
C20H22N4O5•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.
Camostat mesylate (CAS 59721-29-8) References
- Preparation and characterization of biodegradable or enteric-coated microspheres containing the protease inhibitor camostat. | Uchida, T., et al. 2001. J Pharm Pharmacol. 53: 255-61. PMID: 11273024
- Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. | Horiuchi, A., et al. 1990. J Pharmacol Exp Ther. 252: 320-6. PMID: 1688943
- The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. | Ishikura, H., et al. 2007. Life Sci. 80: 1999-2004. PMID: 17433371
- [Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases]. | Togami, K., et al. 2009. Rinsho Ketsueki. 50: 1700-5. PMID: 20068277
- Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation. | Hofmann-Winkler, H., et al. 2020. Crit Care Explor. 2: e0284. PMID: 33225308
- Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions. | Weiss, J., et al. 2021. Chem Biol Interact. 338: 109428. PMID: 33647240
- Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. | Hoffmann, M., et al. 2021. EBioMedicine. 65: 103255. PMID: 33676899
- Protease inhibitor therapy for recessive dystrophic epidermolysis bullosa. In vitro effect and clinical trial with camostat mesylate. | Ikeda, S., et al. 1988. J Am Acad Dermatol. 18: 1246-52. PMID: 3385039
- Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial. | Keitel, V., et al. 2021. Trials. 22: 343. PMID: 34001215
- Structural insights and inhibition mechanism of TMPRSS2 by experimentally known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride to control SARS-coronavirus-2: A molecular modeling approach. | Sonawane, KD., et al. 2021. Inform Med Unlocked. 24: 100597. PMID: 34075338
- The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19. | Li, K., et al. 2021. mBio. 12: e0097021. PMID: 34340553
- A Phase 2 Randomized, Double-Blind, Placebo-controlled Trial of Oral Camostat Mesylate for Early Treatment of COVID-19 Outpatients Showed Shorter Illness Course and Attenuation of Loss of Smell and Taste. | Chupp, G., et al. 2022. medRxiv.. PMID: 35132421
- Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19. | Kosinsky, Y., et al. 2022. Microbiol Spectr. 10: e0216721. PMID: 35412356
- Camostat Mesylate Versus Lopinavir/Ritonavir in Hospitalized Patients With COVID-19-Results From a Randomized, Controlled, Open Label, Platform Trial (ACOVACT). | Karolyi, M., et al. 2022. Front Pharmacol. 13: 870493. PMID: 35935856
- A computational study of potential therapeutics for COVID-19 invoking conceptual density functional theory. | Saloni, ., et al. 2022. Struct Chem. 33: 2195-2204. PMID: 36097582
Inhibitor of:
A430107O13Rik, Antipain dihydrochloride, ASTL, Corin, Coronavirus, CPA2, CPB, Desc4, EG436523, ENSMUSG00000071517, Enterokinase, Gm46, granzyme C, HAI-1, HAI-2, HtrA4, Influenza A m1, Influenza B NP, Kininogen II, KLK, Klk1b4, Klk26, KLKb2, Klkb21, Klkb22, Marapsin 2, Mast Cell Protease, Mast Cell Protease 2, Mast Cell Protease 5, Mast Cell Protease 8, Matriptase, Matriptase-2, MC-CPA, NANP, neuroserpin, Neurotrypsin, PAI-2, PCSK1N, plasminogen, Polyserase-1, Prostasin, Protease, Prothrombin, PRSS16, Prss28, Prss32, Prss34, PRSS35, PRSS37, Prss39, PRSS44, Prss47, PRSS51, PRSSL1, rotavirus C vp4, rotavirus NSP4, S2P, Sec61, Semenogelin-2, SerpinA11, SerpinA1b, SerpinA1c, SerpinA1e, SerpinA2, SerpinA3a, SerpinA3b, SerpinA3c, SerpinA3j, SerpinA3m, SerpinA3n, Serpinb3c, Serpinb3d, SerpinB6B, SerpinB6C, SERPINE3, SPINK14, SPINK2, SPINK3, SPINK7, SPUVE, SR-2C, ST18, SYCE2, TATI, TGE Virus, TMPRSS11B, TMPRSS11F, TMPRSS12, TMPRSS13, TMPRSS2, TMPRSS3, TMPRSS5, TPSB1, TPSB3, Trypsin, Trypsin X3, Trypsin-1, Trypsin-10, Trypsin-4, TSP50, and uPA.Activator of:
1700074P13Rik, Acrosin, Chromozym TRY, Coronavirus nucleocapsid, CPA1, CRISP-8, Desc4, HSBP1L1, KLK15, Klk26, KLKb8, PRSS16, Prss28, Prss29, PRSS35, Prss39, Prss47, SerpinA1a, SERPINE3, TMPRSS11A, TMPRSS11B, TMPRSS11C, TMPRSS11E2, TMPRSS11F, TMPRSS13, TMPRSS3, TMPRSS5, TMPRSS7, TMPRSSs8, TPSB1, and UNQ9391.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Camostat mesylate, 10 mg | sc-203867 | 10 mg | $43.00 | |||
Camostat mesylate, 50 mg | sc-203867A | 50 mg | $183.00 | |||
Camostat mesylate, 500 mg | sc-203867B | 500 mg | $312.00 | |||
Camostat mesylate, 1 g | sc-203867C | 1 g | $624.00 | |||
Camostat mesylate, 10 g | sc-203867D | 10 g | $2081.00 | |||
Camostat mesylate, 100 g | sc-203867E | 100 g | $4474.00 |