CALR3 Antibody (1H2): sc-134295

CALR3 Antibody (1H2) is a mouse monoclonal IgG2b kappa light chain antibody that detects CALR3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CALR3 antibody (1H2) is available as a non-conjugated monoclonal isotype antibody. Calreticulin-3, also known as CRT2, is a crucial endoplasmic reticulum protein composed of 384 amino acids, featuring two calcium-binding domains: a P-domain and a C-domain. CALR3 plays a vital role in the calreticulin/calnexin cycle, which is essential for protein folding, oligomeric assembly, and quality control within the endoplasmic reticulum. Proper functioning of CALR3 ensures that only correctly folded proteins are transported to their final destinations, thereby maintaining cellular homeostasis and preventing the accumulation of misfolded proteins that can lead to cellular stress and disease. CALR3 exhibits specific expression in the testis and has been identified as a cancer-testis antigen, frequently expressed in various cancers, making CALR3 a potential target for cancer immunotherapy.

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CALR3 Antibody (1H2) References:

1. Calreticulin, a multifunctional Ca2+ binding chaperone of the endoplasmic reticulum.  |  Michalak, M., et al. 1998. Biochem Cell Biol. 76: 779-85. PMID: 10353711
2. Calreticulin: one protein, one gene, many functions.  |  Michalak, M., et al. 1999. Biochem J. 344 Pt 2: 281-92. PMID: 10567207
3. The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.  |  Corbett, EF., et al. 2000. J Biol Chem. 275: 27177-85. PMID: 10842171
4. Identification of a novel calreticulin isoform (Crt2) in human and mouse.  |  Persson, S., et al. 2002. Gene. 297: 151-8. PMID: 12384296
5. Phylogenetic analyses and expression studies reveal two distinct groups of calreticulin isoforms in higher plants.  |  Persson, S., et al. 2003. Plant Physiol. 133: 1385-96. PMID: 14563927
6. Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy.  |  Chiu, C., et al. 2007. J Mol Cell Cardiol. 43: 337-43. PMID: 17655857
7. Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis.  |  Hayashi, E., et al. 2007. Clin Cancer Res. 13: 6267-74. PMID: 17975137
8. Calreticulin: conserved protein and diverse functions in plants.  |  Jia, XY., et al. 2009. Physiol Plant. 136: 127-38. PMID: 19453510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CALR3 Antibody (1H2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CALR3 Antibody (1H2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CALR3 Antibody (1H2) Specifications

Alternate Product Name: CALR3

Product Clone Name: 1H2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 21-385

Epitope Target: CALR3

Epitope Species: human

Product Reactivity/Detection: CALR3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CALR3 Antibody (1H2): N/A