Molecular structure of Calpain Inhibitor XII, CAS Number: 181769-57-3
Calpain Inhibitor XII (CAS 181769-57-3)
CAS Number:
181769-57-3
Purity:
≥90%
Molecular Weight:
482.6
Molecular Formula:
C26H34N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 (Ki = 19 nM). Calpain Inhibitor XII may act to inhibit calpain-2 (Ki = 120 nM) and human cathepsin B (Ki= 750 nM) only at higher concentrations. Calpain Inhibitor XII has been reported to induce neutrophile polarization and chemokinesis.
Calpain Inhibitor XII (CAS 181769-57-3) References
- Calpain regulates neutrophil chemotaxis. | Lokuta, MA., et al. 2003. Proc Natl Acad Sci U S A. 100: 4006-11. PMID: 12649322
- Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. | Ma, C., et al. 2020. Cell Res. 30: 678-692. PMID: 32541865
- Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry. | Gurard-Levin, ZA., et al. 2020. Antiviral Res. 182: 104924. PMID: 32896566
- Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L. | Sacco, MD., et al. 2020. Sci Adv. 6: PMID: 33158912
- Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CLpro Inhibitors. | Rawson, JMO., et al. 2021. Viruses. 13: PMID: 33498923
- Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses. | Hu, Y., et al. 2021. ACS Infect Dis. 7: 586-597. PMID: 33645977
- Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. | Kitamura, N., et al. 2022. J Med Chem. 65: 2848-2865. PMID: 33891389
- Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays. | Ma, C., et al. 2022. Acta Pharm Sin B. 12: 1636-1651. PMID: 34745850
- Unbinding ligands from SARS-CoV-2 Mpro via umbrella sampling simulations. | Tam, NM., et al. 2022. R Soc Open Sci. 9: 211480. PMID: 35116157
- Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay. | Cao, W., et al. 2022. ACS Cent Sci. 8: 192-204. PMID: 35229034
- A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors. | Chen, KY., et al. 2022. Antiviral Res. 201: 105272. PMID: 35278581
- Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors. | Hicks, EG., et al. 2022. Bioorg Med Chem Lett. 66: 128732. PMID: 35427739
- SARS-CoV-2 Main Protease Drug Design, Assay Development, and Drug Resistance Studies. | Tan, B., et al. 2023. Acc Chem Res. 56: 157-168. PMID: 36580641
- A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants. | Huang, C., et al. 2023. Signal Transduct Target Ther. 8: 128. PMID: 36928316
- Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. | Li, Z., et al. 1996. J Med Chem. 39: 4089-98. PMID: 8831774
Inhibitor of:
Calpain 1, Calpain 2, and cathepsin B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain Inhibitor XII, 1 mg | sc-300318 | 1 mg | $133.00 | |||
Calpain Inhibitor XII, 5 mg | sc-300318A | 5 mg | $550.00 |