Molecular structure of Calpain Inhibitor VI, CAS Number: 190274-53-4
Calpain Inhibitor VI (CAS 190274-53-4)
See product citations (5)
Alternate Names:
Calpain Inhibitor VI is also known as SJA 6017.
Application:
Calpain Inhibitor VI is a potent and reversible inhibitor of the calcium-dependent cysteine proteases µ-calpain and m-calpain.
CAS Number:
190274-53-4
Purity:
≥95%
Molecular Weight:
372.5
Molecular Formula:
C17H25FN2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Calpain Inhibitor VI is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. Studies indicate that Calpain Inhibitor VI strongly inhibits cathepsin B and cathepsin L. In addition, Calpain Inhibitor VI reduces nuclear opacity and proteolysis of crystallins and α-spectrin induced by A23187 (sc-3591). Studies suggest that substitution at the P1 position, specially a bulky amino acid residual aldehyde, will increase the potency of the Calpain Inhibitor VI. Furthermore, the S-configuration of Calpain Inhibitor VI is important in the inhibition of cathepsin L.
Calpain Inhibitor VI (CAS 190274-53-4) References
- The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. | Kupina, NC., et al. 2001. J Neurotrauma. 18: 1229-40. PMID: 11721741
- Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. | Inoue, J., et al. 2003. J Med Chem. 46: 868-71. PMID: 12593666
- The calpain inhibitor VI prevents apoptosis of adult motor neurons. | Momeni, HR. and Kanje, M. 2005. Neuroreport. 16: 1065-8. PMID: 15973149
- Calpain is activated in degenerating photoreceptors in the rd1 mouse. | Paquet-Durand, F., et al. 2006. J Neurochem. 96: 802-14. PMID: 16405498
- Crystallins in the eye: Function and pathology. | Andley, UP. 2007. Prog Retin Eye Res. 26: 78-98. PMID: 17166758
- Calpain activity in retinal degeneration. | Paquet-Durand, F., et al. 2007. J Neurosci Res. 85: 693-702. PMID: 17171699
- Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice. | Barnard, DL., et al. 2006. Antivir Chem Chemother. 17: 275-84. PMID: 17176632
- Calpain activation and apoptosis in motor neurons of cultured adult mouse spinal cord. | Momeni, HR., et al. 2007. Funct Neurol. 22: 105-10. PMID: 17637214
- Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. | Darnell, GA., et al. 2007. J Biol Chem. 282: 37492-500. PMID: 17977825
- Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. | Schneider, M., et al. 2012. J Virol. 86: 10112-22. PMID: 22787216
- Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2. | Villalpando Rodriguez, GE. and Torriglia, A. 2013. Biochim Biophys Acta. 1833: 2244-53. PMID: 23747342
- Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation. | Zhong, X., et al. 2018. FASEB J. 32: 5312-5325. PMID: 29718706
- Identification of Calpain-Activated Protein Functions. | Del Carmen Lafita-Navarro, M. and Conacci-Sorrell, M. 2019. Methods Mol Biol. 1915: 149-160. PMID: 30617802
Inhibitor of:
Calpain, Calpain 2, Calpain II, cathepsin B, and cathepsin L.Activator of:
Calpain 14.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain Inhibitor VI, 1 mg | sc-293979 | 1 mg | $82.00 | |||
Calpain Inhibitor VI, 5 mg | sc-293979A | 5 mg | $306.00 |