Molecular structure of Calpain Inhibitor I, CAS Number: 110044-82-1
Calpain Inhibitor I (CAS 110044-82-1)
See product citations (10)
Application:
Calpain Inhibitor I is a calpain and cathepsin inhibitor
CAS Number:
110044-82-1
Purity:
≥95%
Molecular Weight:
383.5
Molecular Formula:
C20H37N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Calpain Inhibitor I is an inhibitor of Calpain 1(calpain I) (Ki = 190 nM), Calpain 2(calpain II) (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). It inhibits neutral cysteine proteases and proteasome (Ki = 6 muM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Calpain Inhibitor I inhibits the proteolysis of IkappaBalpha and IkappaBbeta by the ubiquitin-proteasome complex. Furthermore, it protects against neuronal damage caused by hypoxia and ischemia. Calpain Inhibitor I also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Calpain Inhibitor I (CAS 110044-82-1) References
- Calpain inhibitor I retards seizure offset in the hippocampus of freely moving rats. | Sierra-Paredes, G., et al. 1999. Neurosci Lett. 263: 165-8. PMID: 10213161
- Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. | Atencio, IA., et al. 2000. Cell Growth Differ. 11: 247-53. PMID: 10845425
- Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat. | Cuzzocrea, S., et al. 2001. Gut. 48: 478-88. PMID: 11247891
- Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. | Chatterjee, PK., et al. 2001. Kidney Int. 59: 2073-83. PMID: 11380809
- Calpain inhibitor I and colonic inflammation induced by DNBS in the rat. | Ballinger, A. and Azooz, O. 2002. Gut. 50: 440-1. PMID: 11839729
- In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. | Perrin, C., et al. 2002. Cell Mol Biol (Noisy-le-grand). 48 Online Pub: OL267-70. PMID: 12643443
- Calpain inhibitor I reduces intestinal ischemia-reperfusion injury in the rat. | Marzocco, S., et al. 2004. Shock. 21: 38-44. PMID: 14676682
- Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms. | Zhu, H., et al. 2004. Mol Ther. 9: 666-73. PMID: 15120327
- Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. | Sasaki, T., et al. 1990. J Enzyme Inhib. 3: 195-201. PMID: 2079636
- Calpain inhibitor I attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-κB pathway. | Yu, L., et al. 2018. Can J Physiol Pharmacol. 96: 60-67. PMID: 28758430
- Calpain activation in apoptosis. | Squìer, MK., et al. 1994. J Cell Physiol. 159: 229-37. PMID: 8163563
- In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. | Sherwood, SW., et al. 1993. Proc Natl Acad Sci U S A. 90: 3353-7. PMID: 8386372
- Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. | Griscavage, JM., et al. 1996. Proc Natl Acad Sci U S A. 93: 3308-12. PMID: 8622934
- Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. | Lu, Q. and Mellgren, RL. 1996. Arch Biochem Biophys. 334: 175-81. PMID: 8837753
- Nucleotidase activities of the 26 S proteasome and its regulatory complex. | Hoffman, L. and Rechsteiner, M. 1996. J Biol Chem. 271: 32538-45. PMID: 8955078
Inhibitor of:
cathepsin L.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpain Inhibitor I, 25 mg | sc-29119 | 25 mg | $347.00 |