CALCOCO2 Antibody (F-6): sc-376540
- CALCOCO2 Antibody (F-6) is a mouse monoclonal IgG1 κ CALCOCO2 antibody, cited in 11 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 425-445 at the C-terminus of CALCOCO2 of human origin
- CALCOCO2 Antibody (F-6) is recommended for detection of CALCOCO2 of human origin by WB, IP, IF and ELISA
- Anti-CALCOCO2 Antibody (F-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CALCOCO2 Antibody (F-6). This work is in progress.
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CALCOCO2 Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CALCOCO2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CALCOCO2 antibody (F-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CALCOCO2, also known as calcium-binding and coiled-coil domain-containing protein 2 or NDP52 (nuclear dot protein 52), is a 446 amino acid protein that plays a crucial role in organizing the actin cytoskeleton and ruffle formation. CALCOCO2 is predominantly localized to the perinuclear region of the cytoplasm and nuclear dots, where CALCOCO2 acts as a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are thought to be associated with the nuclear matrix and may play a significant role in the life cycles of various viruses, including herpes simplex virus type 1 (HSV-1). CALCOCO2 is expressed ubiquitously, with highest levels found in skeletal muscle, and CALCOCO2 interacts with proteins such as Myosin VI, highlighting CALCOCO2′s importance in cellular processes such as membrane trafficking, cell adhesion, and cytokine signaling. CALCOCO2′s ability to regulate these pathways underscores CALCOCO2′s potential significance in developmental events and cellular responses to external stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CALCOCO2 Antibody (F-6) References:
- Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. | Florin, L., et al. 2002. Virology. 295: 97-107. PMID: 12033769
- HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. | Di, Y., et al. 2003. J Biochem. 133: 713-8. PMID: 12869526
- Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes. | Everett, RD., et al. 2004. J Virol. 78: 1903-17. PMID: 14747555
- T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion. | Morriswood, B., et al. 2007. J Cell Sci. 120: 2574-85. PMID: 17635994
- Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. | Korioth, F., et al. 1995. J Cell Biol. 130: 1-13. PMID: 7540613
- The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1. | Korioth, F., et al. 1996. Exp Cell Res. 229: 155-8. PMID: 8940259
- Cellular localization, expression, and structure of the nuclear dot protein 52. | Sternsdorf, T., et al. 1997. J Cell Biol. 138: 435-48. PMID: 9230084
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CALCOCO2 Antibody (F-6) | sc-376540 | 200 µg/ml | $322.00 | |||
CALCOCO2 Antibody (F-6) AC | sc-376540 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CALCOCO2 Antibody (F-6) HRP | sc-376540 HRP | 200 µg/ml | $322.00 | |||
CALCOCO2 Antibody (F-6) FITC | sc-376540 FITC | 200 µg/ml | $336.00 | |||
CALCOCO2 Antibody (F-6) PE | sc-376540 PE | 200 µg/ml | $349.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 488 | sc-376540 AF488 | 200 µg/ml | $364.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 546 | sc-376540 AF546 | 200 µg/ml | $364.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 594 | sc-376540 AF594 | 200 µg/ml | $364.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 647 | sc-376540 AF647 | 200 µg/ml | $364.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 680 | sc-376540 AF680 | 200 µg/ml | $364.00 | |||
CALCOCO2 Antibody (F-6) Alexa Fluor® 790 | sc-376540 AF790 | 200 µg/ml | $364.00 | |||
CALCOCO2 (F-6) Neutralizing Peptide | sc-376540 P | 100 µg/0.5 ml | $69.00 |