Calcitonin Antibody (14A2): sc-51796
- Calcitonin Antibody (14A2) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant fragment human calcitonin
- recommended for detection of calcitonin and procalcitonin of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Calcitonin Antibody (14A2). This work is in progress.
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Calcitonin Antibody (14A2) is a mouse monoclonal IgG1 antibody that detects Calcitonin in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Calcitonin is a 32 amino acid polypeptide hormone that plays a crucial role in maintaining skeletal integrity and regulating blood calcium levels by inhibiting osteoclast activity in bones, reducing calcium and phosphate reabsorption in kidney tubules, and decreasing calcium absorption in the intestines. The secretion of Calcitonin from the thyroid gland is intricately regulated by estrogen, which enhances Calcitonin mRNA levels, highlighting the hormone′s importance in calcium homeostasis and bone health. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in various mRNA transcripts, including one that encodes procalcitonin and both active polypeptides, Calcitonin and katacalcin. Additionally, an alternative transcript of CALCA produces the neuropeptide Calcitonin gene-related peptide 1 (CGRP1), a potent vasodilatory peptide found in neuronal cells. The presence of CGRP1 and its related gene, CALCB, which encodes CGRP2, underscores the complexity of the CALCA gene family and its significant role in both endocrine and nervous system functions. Anti-Calcitonin antibody (14A2) serves as an essential tool for researchers studying calcium regulation and related physiological processes, providing insights into the intricate mechanisms governing bone health and metabolic balance.
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Calcitonin Antibody (14A2) References:
- Calcitonin and metabolic alkalosis. | Escanero, JF., et al. 1991. Biomed Pharmacother. 45: 307-9. PMID: 1760522
- Renal metabolism of calcitonin. | Simmons, RE., et al. 1988. Am J Physiol. 254: F593-600. PMID: 2833122
- Calcitonin and the peptides from the calcitonin gene. | MacIntyre, I., et al. 1987. Clin Orthop Relat Res. 45-55. PMID: 3549095
- Calcitonin in nonthyroidal cancer. | Schwartz, KE., et al. 1979. J Clin Endocrinol Metab. 49: 438-44. PMID: 468977
- Immunoreactive calcitonin in leukaemia. | Hillyard, CJ., et al. 1979. Br Med J. 2: 1392-3. PMID: 519475
- Calcitonin and prostaglandin system. | Ceserani, R., et al. 1979. Life Sci. 25: 1851-5. PMID: 529990
- Calcitonin in extrathyroidal tissues of man. | Becker, KL., et al. 1979. Acta Endocrinol (Copenh). 92: 746-51. PMID: 532527
- Calcitonin alters behaviour of isolated osteoclasts. | Chambers, TJ. and Magnus, CJ. 1982. J Pathol. 136: 27-39. PMID: 7057295
- Neutralizing antibodies against calcitonin. | Grauer, A., et al. 1993. Horm Metab Res. 25: 486-8. PMID: 8225203
- Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin. | Muff, R., et al. 1995. Can J Physiol Pharmacol. 73: 963-7. PMID: 8846437
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calcitonin Antibody (14A2) | sc-51796 | 100 µg/ml | $322.00 |