Molecular structure of Caged Ins(1,4,5)P3, Trisodium Salt
Caged Ins(1,4,5)P3, Trisodium Salt
Alternate Names:
D-myo-Inositol 1,4,5-Trisphosphate, P4(5)-1-(2-Nitrophenyl)ethyl Ester, 3Na
Application:
Caged Ins(1,4,5)P3, Trisodium Salt is a photo-activated derivative of Ins(1,4,5)P3
Purity:
≥90%
Molecular Weight:
635.2
Molecular Formula:
C14H19NO17P3•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Caged Ins(1,4,5)P3, Trisodium Salt is a photo-activated derivative of Ins(1,4,5)P3. The compound is not biologically active or metabolized by endogenous phosphatase. Caged InsP3 is a combination of two compounds in which InsP3 is esterified with 1(2-nitrophenyl)diazoethane (probably at the P4- or P5-position) and it can be selectively released by irradiation. Research shows that caged probes can be used to assay intracellular receptors.
Caged Ins(1,4,5)P3, Trisodium Salt References
- Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes. | Gregory, RB., et al. 1999. Biochem J. 341 (Pt 2): 401-8. PMID: 10393099
- Elemental propagation of calcium signals in response-specific patterns determined by environmental stimulus strength. | Goddard, H., et al. 2000. Proc Natl Acad Sci U S A. 97: 1932-7. PMID: 10677557
- Calsenilin reverses presenilin-mediated enhancement of calcium signaling. | Leissring, MA., et al. 2000. Proc Natl Acad Sci U S A. 97: 8590-3. PMID: 10900016
- Growth of Pollen Tubes of Papaver rhoeas Is Regulated by a Slow-Moving Calcium Wave Propagated by Inositol 1,4,5-Trisphosphate. | Franklin-Tong, VE., et al. 1996. Plant Cell. 8: 1305-1321. PMID: 12239415
- Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR. | MacMillan, D. and McCarron, JG. 2009. Br J Pharmacol. 158: 1112-20. PMID: 19785652
- Photo-activatable probes for the analysis of receptor function in living cells. | Li, WH. 2010. Methods Mol Biol. 591: 105-20. PMID: 19957126
- Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃. | Haun, S., et al. 2012. Channels (Austin). 6: 379-84. PMID: 22878752
- ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors. | MacMillan, D., et al. 2012. J Cell Sci. 125: 5151-8. PMID: 22899721
- Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. | Walker, JW., et al. Nature. 327: 249-52. PMID: 3494954
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caged Ins(1,4,5)P3, Trisodium Salt, 10 µg | sc-221392 | 10 µg | $259.00 |