Caffeic acid methyl esterAn antioxidant ornithine decarboxylase inhibitor

Caffeic acid methyl ester (CAS 3843-74-1)

Caffeic acid methyl ester | CAS 3843-74-1 is rated 5.0 out of 5 by 1.
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Application: An antioxidant ornithine decarboxylase inhibitor
CAS Number: 3843-74-1
Purity: >98%
Molecular Weight: 194.20
Molecular Formula: C10H10O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caffeic acid methyl ester displays antioxidant, antiproliferative and cytotoxic properties. ODC(Ornithine decarboxylase) and protein tyrosine kinases inhibitor. Caffeic acid methyl ester exhibits a strong inhibitory effect on human platelet aggregation.


References

Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth: C.V. Rao, et al.; Chem. Biol. Interactions 84, 277 (1992) Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb: W.C. Chang & F.L. Hsu; Prostaglandins Leukot. Essent. Fatty Acids 45, 307 (1992) Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell: I.R. Lee & M.Y. Yang; Arch. Pharm. Res. 17, 476 (1994) Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata: M.K. Pyo, et al.; Arch. Pharm. Res. 25, 325 (2002) Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles: J.E. Burdette, et al.; J. Agric. Food Chem. 50, 7022 (2002) Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids: S.M. Fiuza, et al.; Bioorg. Med. Chem. 12, 3581 (2004)

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, DMF, methanol, and acetone.
Storage :
Store at -20° C
Melting Point :
158-161° C
Boiling Point :
367.60° C at 760 mmHg (Predicted)
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
NCI-H1299: IC50 = 3.53 µM (human); HeLa: IC50 = 3.77 µM (human); HOP-62: IC50 = 3.86 µM (human); LoVo: IC50 = 5.80 µM (human); NCI-H1792: IC50 = 6.09 µM (human)
pK Values :
pKa: 8.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
689075
Merck Index :
14: 1635
MDL Number :
MFCD00210468
SMILES :
COC(=O)/C=C/C1=CC(=C(C=C1)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shin Shin, KM. et al. (PubMed 15548379) suggested that the anti-inflammatory effect of Caffeic acid methyl ester is due to its ability to inhibit prostaglandin E2, nitric oxide, and TNF- production. -SCBT Publication Review
Date published: 2015-01-25
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