Molecular structure of Cafestol, CAS Number: 469-83-0
Cafestol (CAS 469-83-0)
See product citations (4)
Application:
Cafestol is an inducer of GST (glutathione S-transferase)
CAS Number:
469-83-0
Purity:
≥98%
Molecular Weight:
316.44
Molecular Formula:
C20H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cafestol, a natural compound present in coffee beans, functions as a glutathione S-transferase (GST) inducer. It has been found to stimulate the production of growth factor-β1 (GF-β1) and potent inducers like mcl-1 protein. Moreover, cafestol has demonstrated the ability to inhibit the synthesis of proinflammatory cytokines and downregulate the expression of inflammatory genes. Furthermore, cafestol displays anti-inflammatory properties by inhibiting prostaglandin synthesis and reducing leukocyte chemotaxis. Cafestol, in addition, inhibits angiogenesis by disrupting the signaling pathways of vascular endothelial growth factor receptors.
Cafestol (CAS 469-83-0) References
- Coffee and its consumption: benefits and risks. | Butt, MS. and Sultan, MT. 2011. Crit Rev Food Sci Nutr. 51: 363-73. PMID: 21432699
- Coffee: biochemistry and potential impact on health. | Ludwig, IA., et al. 2014. Food Funct. 5: 1695-717. PMID: 24671262
- Cafestol Activates Nuclear Factor Erythroid-2 Related Factor 2 and Inhibits Urotensin II-Induced Cardiomyocyte Hypertrophy. | Hao, WR., et al. 2019. Am J Chin Med. 47: 337-350. PMID: 30871360
- Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. | Ren, Y., et al. 2019. Int J Mol Sci. 20: PMID: 31480213
- Cafestol increases fat oxidation and energy expenditure in Caenorhabditis elegans via DAF-12-dependent pathway. | Farias-Pereira, R., et al. 2020. Food Chem. 307: 125537. PMID: 31644978
- Chemical composition and health properties of coffee and coffee by-products. | de Melo Pereira, GV., et al. 2020. Adv Food Nutr Res. 91: 65-96. PMID: 32035601
- Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway. | Ji, J., et al. 2020. Int Immunopharmacol. 84: 106529. PMID: 32344356
- Neuroprotective Effects of Coffee Bioactive Compounds: A Review. | Socała, K., et al. 2020. Int J Mol Sci. 22: PMID: 33374338
- Cafestol Inhibits High-Glucose-Induced Cardiac Fibrosis in Cardiac Fibroblasts and Type 1-Like Diabetic Rats. | Liu, JC., et al. 2020. Evid Based Complement Alternat Med. 2020: 4503747. PMID: 33488743
- Cafestol analogues from Coffea canephora: in vitro inhibition and molecular docking to α-glucosidase. | Hoang, MH., et al. 2022. Nat Prod Res. 1-7. PMID: 36094050
- Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer. | Eldesouki, S., et al. 2022. Molecules. 27: PMID: 36364160
- Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. | Lam, LK., et al. 1982. Cancer Res. 42: 1193-8. PMID: 7059995
- The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. | Cavin, C., et al. 1998. Carcinogenesis. 19: 1369-75. PMID: 9744531
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cafestol, 50 mg | sc-204663 | 50 mg | $356.00 |